METHOD AND APPARATUS FOR AUTOMATED CONTROL OF PACING POST-CONDITIONING
First Claim
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1. A cardiac pacing system, comprising:
- a pacing output circuit to deliver pacing pulses;
a storage device;
one or more pacing post-conditioning (PPC) protocols stored in the storage device, the one or more PPC protocols each specifying a pacing sequence including alternating non-pacing and pacing periods, the non-pacing periods each including a non-pacing duration during which no pacing pulse is timed to be delivered, the pacing periods each including a pacing duration during which a plurality of pacing pulses is timed to be delivered according to a stress augmentation pacing mode adapted to augment myocardial mechanical stress to a level effecting cardioprotection against myocardial injury;
a pacing control circuit coupled to the pacing output circuit and the storage device, the pacing control circuit programmed to execute a current pacing protocol and including;
a parameter input configured to receive one or more protocol generation parameters including at least one or more physiological parameters; and
a protocol generator programmed to generate the current pacing protocol using the one or more PPC protocols and the one or more protocol generation parameters, the current pacing protocol specifying a plurality of pacing parameters, the one or more protocol generation parameters used to calculate one or more pacing parameters of the plurality of pacing parameters.
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Abstract
Pacing post-conditioning (PPC) therapy is applied to a patient to minimize ischemic injury associated with MI and/or reperfusion injury associated with a post-MI revascularization procedure. In various embodiments, a PPC therapy is delivered by executing a pacing protocol with pacing parameters determined and dynamically adjusted based on patient-specific factors to ensure efficacy and safety of the patient.
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Citations
20 Claims
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1. A cardiac pacing system, comprising:
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a pacing output circuit to deliver pacing pulses; a storage device; one or more pacing post-conditioning (PPC) protocols stored in the storage device, the one or more PPC protocols each specifying a pacing sequence including alternating non-pacing and pacing periods, the non-pacing periods each including a non-pacing duration during which no pacing pulse is timed to be delivered, the pacing periods each including a pacing duration during which a plurality of pacing pulses is timed to be delivered according to a stress augmentation pacing mode adapted to augment myocardial mechanical stress to a level effecting cardioprotection against myocardial injury; a pacing control circuit coupled to the pacing output circuit and the storage device, the pacing control circuit programmed to execute a current pacing protocol and including; a parameter input configured to receive one or more protocol generation parameters including at least one or more physiological parameters; and a protocol generator programmed to generate the current pacing protocol using the one or more PPC protocols and the one or more protocol generation parameters, the current pacing protocol specifying a plurality of pacing parameters, the one or more protocol generation parameters used to calculate one or more pacing parameters of the plurality of pacing parameters. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for cardiac pacing, comprising:
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receiving at least one pacing post-conditioning (PPC) protocol from a storage device storing one or more PPC protocols each specifying a pacing sequence, the pacing sequence including alternating non-pacing and pacing periods, the non-pacing periods each including a non-pacing duration during which no pacing pulse is timed to be delivered, the pacing periods each including a pacing duration during which a plurality of pacing pulses is timed to be delivered according to a stress augmentation pacing mode adapted to augment myocardial mechanical stress to a level effecting cardioprotection against myocardial injury; receiving one or more protocol generation parameters including at least one or more physiological parameters; generating a current pacing protocol specifying a plurality of pacing parameters using the at least one PPC protocol and the one or more protocol generation parameters; controlling delivery of pacing pulses from a cardiac pacemaker by executing the current pacing protocol. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification