THERAPEUTIC METHODS AND COMPOSITIONS
First Claim
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1. A method for inhibiting fibroblast activation in a tumor environment, the method comprising inhibiting the activity of lysyl oxidase-like 2 (LOXL2).
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Abstract
Disclosed herein are methods for modulating the environment of a tumor, by inhibiting the activity of the extracellular enzyme lysyl oxidase-like 2 (LOXL2). The methods disclosed herein are effective in reducing tumor growth, reducing recruitment of cells to the tumor, reducing fibroblast activation, reducing desmoplasia, reducing vasculogenesis, reducing the number of TAFs, reducing growth factor production, inhibiting collagen deposition, and increasing necrosis and pyknosis in the tumor. Exemplary inhibitors of LOXL2 activity are antibodies and siRNAs.
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Citations
61 Claims
- 1. A method for inhibiting fibroblast activation in a tumor environment, the method comprising inhibiting the activity of lysyl oxidase-like 2 (LOXL2).
- 7. A method for inhibiting desmoplasia in a tumor environment, the method comprising inhibiting the activity of lysyl oxidase-like 2 (LOXL2).
- 9. A method for inhibiting vasculogenesis in a tumor environment, the method comprising inhibiting the activity of lysyl oxidase-like 2 (LOXL2).
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14. A method for reducing the number of tumor-associated fibroblasts (TAFs) in a tumor stroma, the method comprising inhibiting the activity of lysyl oxidase-like 2 (LOXL2).
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15. A method for inhibiting collagen deposition in a tumor environment, the method comprising inhibiting the activity of lysyl oxidase-like 2 (LOXL2).
- 16. A method for modulating a tumor environment, the method comprising inhibiting the activity of lysyl oxidase-like 2 (LOXL2).
- 30. A method for modulating the production of growth factors in a tumor environment, the method comprising inhibiting the activity of lysyl oxidase-like 2 (LOXL2).
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32. A method for increasing necrosis in a tumor, the method comprising inhibiting the activity of lysyl oxidase-like 2 (LOXL2).
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33. A method for increasing pyknosis in a tumor, the method comprising inhibiting the activity of lysyl oxidase-like 2 (LOXL2).
- 40. A method for identifying an inhibitor of LOXL2, the method comprising assaying a test molecule for its ability to modulate a tumor environment.
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