METHODS OF INHIBITING UNWANTED CELL PROLIFERATION USING HEDGEHOG ANTAGONISTS
First Claim
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1. A method of inhibiting unwanted cell proliferation associated with cancer in a tissue comprising,determining whether said tissue overexpresses a gli-1 gene, andcontacting said tissue that overexpresses a gli-1 gene with an effective amount of a hedgehog antibody, which hedgehog antibody binds to Sonic hedgehog protein and inhibits hedgehog signaling;
- whereby said hedgehog antibody causes decreased cell proliferation in the tissue, andwherein the cancer is associated with one or more of prostate, breast, bladder, or colon tissues.
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Abstract
The present application is directed to compositions and methods for inhibiting angiogenesis and treating or preventing unwanted cell proliferation, including tumors, by inhibiting the hedgehog pathway, e.g., with an antagonist of the hedgehog pathway such as those disclosed herein.
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Citations
53 Claims
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1. A method of inhibiting unwanted cell proliferation associated with cancer in a tissue comprising,
determining whether said tissue overexpresses a gli-1 gene, and contacting said tissue that overexpresses a gli-1 gene with an effective amount of a hedgehog antibody, which hedgehog antibody binds to Sonic hedgehog protein and inhibits hedgehog signaling; -
whereby said hedgehog antibody causes decreased cell proliferation in the tissue, and wherein the cancer is associated with one or more of prostate, breast, bladder, or colon tissues. - View Dependent Claims (2, 3, 4, 6, 7, 9, 23, 24, 25, 26)
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- 5. A method for treating a tumor in a patient, comprising determining whether the tumor overexpresses a gli-1 gene and administering to said patient an amount of a hedgehog antibody sufficient to decrease at least one of the growth or proliferation of the tumor, which hedgehog antibody binds to Sonic hedgehog protein and inhibits hedgehog signaling, wherein the tumor overexpresses a gli-1 gene and wherein the tumor is associated with at least one of urogenital, lung, breast, prostate, bladder, or colon cancer.
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15. A method for treating colon cancer, comprising
determining whether colon cancer tissue overexpresses a gli-1 gene and administering to a patient in need thereof an amount of a hedgehog antibody sufficient to decrease at least one of the growth or proliferation of the colon cancer tissue, wherein the colon cancer tissue overexpresses a gli-1 gene, and wherein the hedgehog antibody binds to Sonic hedgehog protein and inhibits hedgehog signaling.
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16. A method of inhibiting unwanted cell proliferation in colon cancer tissue comprising,
determining whether said tissue overexpresses a gli-1 gene, and contacting said tissue that overexpresses a gli-1 gene with an effective amount of a hedgehog antibody, which hedgehog antibody binds to Sonic hedgehog protein and inhibits hedgehog signaling; whereby said hedgehog antibody causes decreased cell proliferation in the colon cancer tissue. - View Dependent Claims (29, 30)
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43. A method for treating colon cancer in a patient in need thereof, comprising ascertaining whether colon cancer tissue overexpresses a gli-1 gene, and administering to said patient in need thereof an amount of a hedgehog antibody sufficient to decrease at least one of the growth or proliferation of the colon cancer tissue, wherein the hedgehog antibody binds to Sonic hedgehog protein and inhibits hedgehog signaling, and wherein the colon cancer tissue overexpresses a gli-1 gene.
- 44. A method for treating a tumor in a patient, comprising determining whether the tumor overexpresses a Sonic hedgehog gene and administering to said patient an amount of a hedgehog antibody sufficient to decrease at least one of the growth or proliferation of the tumor, which hedgehog antibody binds to Sonic hedgehog protein and inhibits hedgehog signaling, wherein the tumor overexpresses a Sonic hedgehog gene and wherein the tumor is associated with at least one of urogenital, breast, prostate, bladder, or colon cancer.
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46. A method for treating colon cancer in a patient in need thereof, comprising ascertaining whether colon cancer tissue overexpresses a Sonic hedgehog gene and administering to said patient in need thereof an amount of a hedgehog antibody sufficient to decrease at least one of the growth or proliferation of the colon cancer tissue, wherein the hedgehog antibody binds to Sonic hedgehog protein and inhibits hedgehog signaling, and wherein the colon cancer tissue overexpresses a Sonic hedgehog gene.
- 47. A method for treating a tumor in a patient in need thereof, comprising ascertaining whether the tumor overexpresses a Sonic hedgehog gene, and administering to said patient in need thereof an amount of a hedgehog antibody sufficient to decrease at least one of the growth or proliferation of the tumor, which hedgehog antibody binds to Sonic hedgehog protein and inhibits hedgehog signaling, wherein the tumor overexpresses a Sonic hedgehog gene, and wherein the tumor is associated with at least one of urogenital, breast, prostate, bladder, or colon cancer.
Specification