RETINOID-CONTAINING SUSTAINED RELEASE INTRAOCULAR IMPLANTS AND RELATED MATTERS
First Claim
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1. A biodegradable intraocular drug delivery system comprising:
- a retinoid component and a biodegradable polymer matrix that releases drug at a rate effective to sustain release of an amount of the retinoid component from the drug delivery system for at least about one week after the drug delivery system is placed in an eye.
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Abstract
Biocompatible intraocular implants include a retinoid component and a biodegradable polymer that is effective to facilitate release of the retinoid component into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as retinal damage, including glaucoma and proliferative vitreoretinopathy.
23 Citations
31 Claims
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1. A biodegradable intraocular drug delivery system comprising:
a retinoid component and a biodegradable polymer matrix that releases drug at a rate effective to sustain release of an amount of the retinoid component from the drug delivery system for at least about one week after the drug delivery system is placed in an eye. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method of making a biodegradable intraocular drug delivery system, comprising the step of:
- extruding a mixture of a retinoid and a biodegradable polymer component to form a biodegradable material that degrades at a rate effective to sustain release of an amount of the retinoid from the drug delivery system for at least about one week after the drug delivery system is placed in an eye.
- View Dependent Claims (19, 20, 21, 22, 23)
- 24. A method of improving or maintaining vision in an eye of a patient, comprising the step of placing a biodegradable intraocular drug delivery system in an eye of the patient, the drug delivery system comprising a retinoid component and a biodegradable polymer matrix, wherein the drug delivery system degrades at a rate effective to sustain release of an amount of the retinoid component from the drug delivery system effective to improve or maintain vision in the eye of the patient.
Specification