Biopsy marker composition and method of use

• US 20110077512A1
• Filed: 06/16/2010
• Published: 03/31/2011
• Est. Priority Date: 06/16/2009
• Status: Abandoned Application

• Current Assignee: Dept of Veterans' Affairs (Commonwealth of Australia)
• Original Assignee: Dept of Veterans' Affairs (Commonwealth of Australia)
• Inventors: Boswell, John S.
• Application Number:
  US12/801,605
• Publication Number:
  US 20110077512A1
• Time in Patent Office: Days
• US Class Current: 600/431
• CPC Class Codes: A61B 10/02 Instruments for taking cell samples or for biopsy A61B10/0038 and A61B10/0045 take precedence; needle locating or guiding means A61B17/3403; samplers for enzymology or microbiology C12M1/26; sampling or preparing biological specimens G01N33/48
• CPC Class Codes: A61B 2090/3933 Liquid markers
• CPC Class Codes: A61B 2090/3941 Photoluminescent markers
• CPC Class Codes: A61B 2090/395 with marking agent for marking skin or other tissue
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61K 49/0017 Fluorescence in vivo
• CPC Class Codes: A61K 49/0076 dispersion, suspension, e.g. particles in a liquid, colloid, emulsion

Abstract

An aqueous suspension of titanium dioxide, polymethylmethacrylate and Vitamin E oil is used to mark a location wherein a skin biopsy has been taken to enable subsequent identification of the biopsy location under ultraviolet light. The location is advantageously treated with Vitamin E oil on a daily basis subsequently extend the fluorescing life of the applied titanium dioxide.

Claims

1. A marker composition for application to a human or animal for identification of a location of interest under ultraviolet light, the composition being invisible in ordinary light, the composition comprising an aqueous suspension of titanium dioxide and polymethylmethacrylate (PMMA).

2. The marker composition of claim 1, wherein the aqueous suspension comprises 2.5 wt % titanium dioxide and 97.5 wt % PMMA.

3. The marker composition of claim 2, including Vitamin E oil.

4. The marker composition of claim 2, including a aqueous aluminum chloride solution.

5. The marker composition of claim 2, including an effective amount of Lidocaine.

6. The marker composition of claim 2, including an effective amount of epinephrine.

7. The marker composition of claim 2, including an effective amount of an anesthetic.

8. A method of marking an external or internal location of a human being or animal for subsequent identification for medical purposes, said method comprising (a) applying a marker composition which comprises an aqueous suspension of titanium dioxide and polymethylmethacrylate at the location, and (b) irradiating the human or animal with ultraviolet light to cause fluorescing of said titanium dioxide.

9. The method of claim 8, wherein in step (a) the aqueous suspension is applied to an external location.

10. The method of claim 9, wherein in step (a) the aqueous suspension is injected beneath a surface of the location.

11. A method of marking a specific location on the skin of a person where a biopsy has been taken, said method comprising (a) applying a composition to the specific location which comprises an aqueous suspension of titanium dioxide, polymethylmethacrylate and Vitamin E oil, and (b) irradiating the person with ultraviolet light to cause fluorescing of the titanium dioxide at the specific location.

12. An applicator device for marking a location on a human or animal, said applicator device comprising an absorbent material impregnated with an aqueous suspension of titanium dioxide, polymethylmethacrylate and Vitamin E oil.

13. The applicator device of claim 12, comprising a band-aid with a pad impregnated with said aqueous suspension.

14. The applicator device of claim 12, comprising a swab having a cotton tip impregnated with said aqueous suspension.