PORTABLE PNEUMOTACHOGRAPH FOR MEASURING COMPONENTS OF AN EXPIRATION VOLUME

• US 20110077545A1
• Filed: 06/03/2009
• Published: 03/31/2011
• Est. Priority Date: 06/05/2008
• Status: Abandoned Application

• Current Assignee: Aerocrine AB (Circassia Group Plc)
• Original Assignee: Filt Lungen- und Thoraxdiagnostik GmbH
• Inventors: Eichler, Ruediger
• Application Number:
  US12/996,071
• Publication Number:
  US 20110077545A1
• Time in Patent Office: Days
• US Class Current: 600/538
• CPC Class Codes: A61B 5/082 Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath A61B5/083, A61B5/091 take precedence
• CPC Class Codes: A61B 5/091 Measuring volume of inspired or expired gases, e.g. to determine lung capacity
• CPC Class Codes: A61B 5/097 Devices for facilitating collection of breath or for directing breath into or through measuring devices
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: B01D 53/268 by diffusion

Abstract

A portable pneumotachograph for determining components in an exhalation volume. The problem of extreme sensitivity of sensors to the temperature and moisture content of the gases, and cross-sensitivities to other potential components of the exhalation gas, is solved by providing a climate control chamber wherein a defined gas atmosphere can be set such that by means of the climate control chamber the relative humidity and/or the temperature and/or the composition of a sample and/or calibration gas can be set to predefined parameters.

Claims

1. A portable pneumotachograph for determining components in an expiration volume, comprising a processor (4), a PEEP valve (5) attached on the pneumotachograph (1) at the exhalation side, a filter (6) attached on the pneumotachograph (1) at the inhalation side for removing the portion of components to be determined in the inspiration air, at least one sampling unit (8) attached in or on the pneumotachograph tube (2), a valve (10) connected to the sampling unit (8), at least one sensor (7) provided outside of the pneumotachograph tube for determining one of the components in the expiration volume, and a pump (13) disposed downstream of the sensor (7), wherein a chemically and/or physically modified hose (18), which is enclosed by a climate control chamber (15) for conditioning the sample gas and/or calibration gas flowing through the hose (18), is provided between the valve (10) and the sensor (7), and wherein the sample and/or calibration gases to be conditions can be conducted in the hose through the climate control chamber, and in the climate control chamber (15) a defined gas atmosphere can be set such that by means of the climate control chamber (15) the relative humidity and/or the temperature and/or the composition of the sample and/or calibration gas flowing through the hose (18) can be set to predefined parameters.

2. A portable pneumotachograph according to claim 1, wherein the relative humidity of the gas flowing through the hose (18) can be adjusted to values of 0% to 100% RH.

3. A portable pneumotachograph according to claim 1, wherein the chemically and/or physically modified hose (18) is permeable to water vapour and is preferably a Nafion®

hose.

4. A portable pneumotachograph according to claim 1, wherein a humidity sensor (17) and/or temperature sensor (16) is provided in the climate control chamber (15).

5. A portable pneumotachograph according to claim 1, wherein the volume flow of the gas in the hose (18) is 1 to 20 ml/s, preferably 2 to 3 ml/s, and can be set as a function of the purge time of the measuring chamber (14) of the sensor (7) and the feeding system (8, 9, 10, 18, 33, 35) leading to the sensor (7).

6. A portable pneumotachograph according to claim 1, wherein the climate control chamber (15) is equipped with a, preferably controllable, means for controlling the temperature in the climate control chamber (34).

7. A portable pneumotachograph according to claim 6, wherein the means for controlling the temperature (34) is a Peltier element or a resistance heating element.

8. A portable pneumotachograph according to claim 1, wherein the climate control chamber (15) is equipped with a means for setting a defined relative humidity in the climate control chamber (15).

9. A portable pneumotachograph according to claim 8, wherein the means for setting the humidity is a water-storing medium, preferably a water-impregnated cotton pad, or a water-binding medium, preferably of silica gel.

10. A portable pneumotachograph according to claim 8, wherein the means for setting the humidity is a device having two containers (25, 26), each containing a gas of a defined relative humidity, wherein the moisture contents of the two gases are different from one another, wherein the container (25, 26) are connected to the climate control chamber (15) via a common controllable mixing valve (28), and by means of the mixing valve (28) the relative humidity of the gas in the climate control chamber (15) can be set in a process-controlled manner by mixing the two gases from the containers (25, 26) based on measurement values of the humidity sensor (17) which are converted into control signals.

11. A portable pneumotachograph according to claim 10, wherein a heating element (27) is provided for controlling the temperature in the containers (25, 26).

12. A portable pneumotachograph according to claim 10, wherein between climate control chamber (15) and mixing valve (28), a mixing chamber (29) is provided having a humidity sensor (31) and a temperature sensor (32).

13. A portable pneumotachograph according to claim 1, wherein the valve (10) is a static three-way valve.

14. A portable pneumotachograph according to claim 1, wherein the sensor (7) is selected from the group of “

electrochemical sensor, chemiluminescence sensor, enzymatic sensor, immunoassay sensor, NO sensor, O₂ sensor, H₂O₂ sensor, CO₂ sensor, CO sensor, sensor for biomarkers, ion mobility spectrometry (IMS) sensor” and

/or a combined sensor system of said sensors.

15. A portable pneumotachograph according to claim 14, wherein the sensor (7) is an electrochemical nitric oxide sensor, preferably having a measuring rage of 0 to 5000 ppb, preferably 0 to 3000 ppb, more preferably 0 to 1000 ppb, in particular 0 to 500 ppb.

16. A portable pneumotachograph according to claim 1, wherein the pneumotachograph tube (2) has a valve or flap (24) in the inlet for the inspiratory air which can be closed, wherein the pneumotachograph tube has multiple outlets for the expiratory air, wherein outlet valves are provided in the outlets for the expiratory air, wherein by means of the flow meter the volume flow of the expiratory air can be measured and, based on this value, it can be split up into theoretical values of partial volume flows by means of a processor-aided calculation, wherein the partial volume flows can be assigned to different zones of the respiratory tract, wherein the valve or flap (24) in the inlet for the inspiratory air and/or the outlet valves can be driven and controlled by the processor (4), and wherein the operational states of “

closed”

(a) or “

open”

(b) of the valve or flap (24) in the inlet for the inspiratory air and/or the outlet valves can be set according to a particular partial volume flow of the volume flow of the expiratory air.

17. A portable pneumotachograph according to claim 1, wherein the PEEP valve (5) is a double valve which limits the flow between a minimum flow and a maximum flow.

18. A portable pneumotachograph according to claim 1, wherein the chemically and/or physically modified hose (18) for removing compounds in the sampling or calibration gas interfering with the sensory measurement is filled entirely or partially with a filter material and/or the internal wall of the hose is covered with a chemically or physically active film.

19. A portable pneumotachograph according to claim 1, wherein a processor (14) is provided for controlling the climate control chamber (15) and/or the mixing chamber (29).

20. A portable pneumotachograph according to claim 1, wherein in the conduit carrying sample and/or calibration gas, one or more temperature and/or humidity sensors are provided before or after the climate control chamber.