SERVO CONTROL CIRCUIT FOR DETECTING ANALYTES VIA NANOPARTICLE-LABELED SUBSTANCES WITH ELECTROMAGNETIC READ-WRITE HEADS

• US 20110077902A1
• Filed: 09/22/2010
• Published: 03/31/2011
• Est. Priority Date: 09/28/2009
• Status: Active Grant

• Current Assignee: Globalfoundries US Incorporated (GlobalFoundries, Inc.)
• Original Assignee: International Business Machines Corporation
• Inventors: Boday, Dylan Joseph, Awezec, Tara L., Schwartz, Stephen Leonard, Topol, Anna W., Winarski, Daniel James
• Granted Patent: US 8,694,280 B2
• Time in Patent Office: Days
• US Class Current: 702/151
• CPC Class Codes: B82Y 15/00 Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• CPC Class Codes: G01N 33/54326 Magnetic particles
• CPC Class Codes: G01N 33/54333 Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
• CPC Class Codes: G01N 33/54346 Nanoparticles

Abstract

A circuit for controlling an electromagnetic head module to detect antigens on a biosample track comprising a processor for receiving position-error-servo signal from the PES read sensor, a write head for magnetizing nanoparticles attached to antigens, and a read sensor for detecting the nanoparticle-labeled antigens. The circuit may further comprise an X-axis actuator for controlling the head module in the direction perpendicular to the track and an Y-axis actuator coupled to the head module and the X-axis actuator for controlling the head module in the direction of the track. Target antigens are attached to the biosample track and nanoparticles via antibodies.

Claims

1. A circuit for controlling a head module to detect antigens from a biosample track, the head module having a position-error-servo (PES) read sensor for reading servo-alignment marks along the biosample track, the circuit comprising:

a processor for receiving position-error-servo signals from the PES read sensor;

an electromagnetic write head for magnetizing a plurality of nanoparticles labeling the antigens;

a magneto-resistive read sensor for detecting the antigens via the nanoparticles, the write head and the read sensor being part of the head module; and

a plurality of actuators coupled to the head module for controlling the motion of the head module based on the position-error-servo signals.

2. The circuit of claim 1, wherein the actuators comprise an X-axis actuator for controlling the head module in the direction perpendicular to the direction of the biosample track and an Y-axis actuator for controlling the head module in the direction of the biosample track.

3. The circuit of claim 2, wherein the processor sends a signal to the X-axis actuator to center the write head and the read sensor on the biosample track based on the servo-alignment marks.

4. The circuit of claim 3, wherein the processor sends the signal to the X-axis actuator through a power amplifier coupled to the X-axis actuator.

5. The circuit of claim 2, wherein the processor sends a signal to the Y-axis actuator to perform a scan by the head module linearly in the direction of the biosample track.

6. The circuit of claim 5, wherein the processor sends the signal to the Y-axis actuator through a power amplifier coupled to the Y-axis actuator.

7. The circuit of claim 2, wherein the processor sends a signal to the Y-axis actuator to stop the motion of the head module in the direction of the track in response to the PES read sensor reading a predetermined number of servo-alignment marks.

8. The circuit of claim 1, wherein the servo-alignment marks comprise a Z-pattern and the processor calculates the velocity of the head module based on predetermined segments in the Z-pattern and transit time of the head module across the segments.

9. The circuit of claim 8, wherein the processor controls the Y-axis actuator to maintain the head module at a constant speed relative to the biosample track based on the calculated velocity.

10. The circuit of claim 1, wherein the head module is maintained in linear alignment with the biosample track based on the servo-alignment marks.

11. The circuit of claim 1, wherein the servo-alignment marks are on a servo track parallel to the biosample track.

12. The circuit of claim 1, wherein the position of the head module along the biosample track is determined based on the number of the servo-alignment marks read by the PES read sensor.

13. The circuit of claim 1, wherein the servo-alignment marks are timing based servo (TBS) marks.

14. A system for detecting nanoparticle-labeled antigens, comprising:

a biosample track deposited on a magnetic tape media and having the nanoparticle-labeled antigens attached thereon;

a head module having a position-error-servo (PES) read sensor for reading servo-alignment marks along the biosample track, an electromagnetic write head for writing to the tape media to magnetize the nanoparticles, and a magneto-resistive read sensor for reading the tape media to detect the antigens via the nanoparticles; and

a circuit for controlling the head module, the circuit comprising a processor for receiving position-error-servo signals from the PES read sensor, an X-axis actuator for controlling the head module in the direction perpendicular to the track, and an Y-axis actuator for controlling the head module in the direction of the track.

15. The system of claim 14, wherein the head module and circuit are part of a magnetic tape drive.

16. The system of claim 14, wherein biosample track is deposited on a substrate and the head module moves relative to the substrate linearly in the direction of the biosample track during the writing and reading of the tape media.

17. The system of claim 16, wherein the head module is stationary and the substrate is swept across the head module linearly in the direction of the biosample track during the writing and reading of the tape media.

18. The system of claim 14, wherein the head module is a helical-scan rotary head and the biosample track is deposited on a flexible media moving at an angle to the Y-axis of the helical-scan rotary head.

19. The system of claim 14, wherein the PES read sensor is selected from the group consisting of an anisotropic magneto-resistive (AMR) read sensor, a giant magneto-resistive (GMR) read-sensor, and a tunnel magneto-resistive (TMR) read-sensor.

20. The system of claim 14, wherein the servo-alignment marks are timing based servo (TBS) marks.

21. The system of claim 14, wherein the servo-alignment marks are magnetically encoded on a substrate on which the biosample track is deposited.

22. The system of claim 14, wherein the servo-alignment marks are magnetically encoded on a magnetic tape adhered to a substrate on which the biosample track is deposited.

23. The system of claim 14, wherein the servo-alignment marks are magnetically encoded on a magnetic recording layer deposited on a substrate on which the biosample track is deposited.