MOLECULAR IMPRINTED THREE-DIMENSIONALLY ORDERED MACROPOROUS SENSOR AND METHOD OF FORMING THE SAME
First Claim
1. A macroporous sensor, said sensor comprising:
- a target template having a plurality of pores formed by vertical deposition of a plurality of organic polymer particles on a substrate;
an active monomer added to a solution during an infiltration operation with respect to said target template, wherein said active monomer is associated with a plurality of ligands and is polymerized about said target template; and
a macroporous electrode, wherein said target template is removable to form said macroporous electrode for use in sensing operations by said macroporous sensor.
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Abstract
A molecular imprinted three-dimensionally ordered macroporous (MiTOM) sensor for detecting small organic molecules and a method of forming the same. A target template associated with a number of pores can be formed by vertical deposition of organic polymer particles on a substrate. Active monomers can be added to a solution during an infiltration process of the target template. The monomers associated with ligands can be polymerized around the target template so that the ligands can be stereochemically fixed at precise binding sites associated with the target template. The target template can then be removed in order to form a MiTOM sensor electrode, which includes an inverse opal structure. Additionally, an inverse opal backbone structure can be formed and coated with the layer of target template and active monomers in order to form molecular imprinted active sites on the inverse opal backbone structure after a self-assembly and polymerization process.
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Citations
20 Claims
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1. A macroporous sensor, said sensor comprising:
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a target template having a plurality of pores formed by vertical deposition of a plurality of organic polymer particles on a substrate; an active monomer added to a solution during an infiltration operation with respect to said target template, wherein said active monomer is associated with a plurality of ligands and is polymerized about said target template; and a macroporous electrode, wherein said target template is removable to form said macroporous electrode for use in sensing operations by said macroporous sensor. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A molecular imprinted three-dimensionally ordered macroporous sensor, said sensor comprising:
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a substrate; a target template that includes a plurality of pores configured by deposition of a plurality of organic polymer particles on said substrate; an active monomer added to a solution during an infiltration operation with respect to said target template, wherein said active monomer is associated with a plurality of ligands and is polymerized proximate to said target template; and a molecularly imprinted macroporous electrode, wherein said target template is removable to form said molecularly imprinted macroporous electrode, said molecularly imprinted macroporous electrode having an ordered, three-dimensional structure and utilized by said molecular imprinted three-dimensionally ordered macroporous sensor for use in sensing operations. - View Dependent Claims (9, 10, 11, 12, 13, 14)
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15. A method of configuring a macroporous sensor, said sensor comprising:
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configuring a plurality of organic polymer particles on a substrate via a vertical deposition operation to form a target template having a plurality of pores; adding an active monomer to a solution during an infiltration operation with respect to said target template, said active monomer is associated with a plurality of ligands and is polymerized about said target template; and said target template is removable to form a macroporous electrode for use in sensing operations by said macroporous sensor. - View Dependent Claims (16, 17, 18, 19, 20)
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Specification