METHOD OF CONTROLLING DIFFUSIVE SODIUM TRANSPORT IN DIALYSIS

• US 20110079558A1
• Filed: 10/01/2010
• Published: 04/07/2011
• Est. Priority Date: 10/01/2009
• Status: Active Grant

• Current Assignee: Fresenius Medical Care Holdings Incorporated (Fresenius Medical Care AG)
• Original Assignee: Fresenius Medical Care Holdings Incorporated (Fresenius Medical Care AG)
• Inventors: Penne, Erik Lars, Thijssen, Stephan, Levin, Nathan W., Raimann, Jochen G., Kotanko, Peter
• Granted Patent: US 8,518,260 B2
• Time in Patent Office: Days
• US Class Current: 210/647
• CPC Class Codes: A61M 1/1613 Profiling or modelling of patient or predicted treatment evolution or outcome
• CPC Class Codes: A61M 1/1654 Dialysates therefor
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient

Abstract

A method of controlling diffusive sodium transport from the dialysate solution to the blood of a patient undergoing hemodialysis treatment or from the blood to the dialysate solution includes calculating SNa⁺_average, an average of the patient'"'"'s historic serum sodium concentrations, and estimating SNa⁺_estimated, the patient'"'"'s pre-dialysis serum sodium concentration, based on the average of the patient'"'"'s measured historic pre-dialysis serum sodium concentrations, SNa⁺_measured. The method enables adjusting DNa⁺, the sodium concentration of the dialysate solution, based on the average of the patient'"'"'s historic serum sodium concentrations, SNa⁺_average, if needed, and performing the dialysis treatment of the patient using a dialysate solution containing a sodium concentration DNa⁺.

Claims

1. A method of controlling diffusive sodium transport from dialysate solution to blood of a patient undergoing hemodialysis treatment or from blood into the dialysate solution comprising:

a) calculating SNa⁺_average, an average of the patient'"'"'s measured historic serum sodium concentrations, SNa⁺_measured;

b) estimating SNa⁺_estimated, the patient'"'"'s pre-dialysis serum sodium concentration, based on the average, SNa⁺_average, of the patient'"'"'s historic pre-dialysis serum sodium concentrations; and

c) performing the dialysis treatment of the patient using a dialysate solution containing a sodium concentration DNa⁺ based upon SNa⁺_estimated.

2. The method of claim 1, wherein the patient'"'"'s pre-dialysis serum sodium concentration is estimated as equal to the average of the patient'"'"'s historic serum sodium concentrations measured pre-dialysis treatment over a historic time interval.

3. The method of claim 1, wherein the patient'"'"'s historic serum sodium concentrations include corrections for void volume and Gibbs-Donnan effect.

4. The method of claim 2, wherein DNa⁺=SNa⁺_estimated.

5. The method of claim 2, wherein the historic time interval is at least 2 months.

6. The method of claim 2, wherein the historic time interval is at least 4 months.

7. The method of claim 3, wherein DNa⁺=SNa⁺_estimated.

8. The method of claim 3, wherein the historic time interval is at least 2 months.

9. The method of claim 3, wherein the historic time interval is at least 4 months.