STABLE METAL ION-LIPID POWDERED PHARMACEUTICAL COMPOSITIONS FOR DRUG DELIVERY AND METHODS OF USE
First Claim
1. A microparticle for drug delivery wherein the microparticle is comprised of a metal ion-lipid complex, wherein the metal ion is chosen from the group consisting of lanthanide metals, actinide metals, group IIa and IIIb metals, transition metals or mixtures thereof, wherein the lipid comprises a phospholipid and wherein the complex results in a transition temperature increase sufficient to stabilize against water sorption.
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Abstract
Microparticle compositions comprising metal ion-lipid complexes for drug delivery are described including methods of making the microparticle compositions and methods of treating certain conditions and disease states by administering the microparticle compositions. The metal ion-lipid complexes can be combined with various drugs or active agents for therapeutic administration. The microparticle compositions of the present invention have superior stability to other microparticle compositions resulting in a microparticle composition with longer shelf life and improved dispersability. The microparticle compositions of the present invention have a transition temperature (Tg) of at least 20° C. above the recommended storage temperature (Tst) for drug delivery.
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Citations
63 Claims
- 1. A microparticle for drug delivery wherein the microparticle is comprised of a metal ion-lipid complex, wherein the metal ion is chosen from the group consisting of lanthanide metals, actinide metals, group IIa and IIIb metals, transition metals or mixtures thereof, wherein the lipid comprises a phospholipid and wherein the complex results in a transition temperature increase sufficient to stabilize against water sorption.
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2-45. -45. (canceled)
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58. A stable microparticle composition for drug delivery wherein the microparticle is comprised of a metal ion-lipid complex formed by the following process:
- dispersing a phospholipid in water to create a first preparation;
suspending a metal compound or salt in water to create a second preparation;
adding a drug or active agent;
combining the first and second preparations; and
, spray drying the combined preparations to create a stable metal ion-lipid microparticle composition. - View Dependent Claims (59, 60, 61, 62, 63)
- dispersing a phospholipid in water to create a first preparation;
Specification