Methods and compositions for treating neuropathies
First Claim
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1. A zinc finger protein that modulates expression of NT-3 or GDNF, wherein the engineered zinc finger protein comprises the recognition helices shown in a single row of Tables 1 or 4.
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Abstract
Disclosed herein are methods and compositions for treating neuropathies by modulating endogenous NT-3 of GDNF gene expression.
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Citations
21 Claims
- 1. A zinc finger protein that modulates expression of NT-3 or GDNF, wherein the engineered zinc finger protein comprises the recognition helices shown in a single row of Tables 1 or 4.
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13. A method of treating or preventing a condition characterized by neuropathy, the method comprising
administering a zinc finger protein that activates NT-3 or GDNF expression to a subject in need thereof.
Specification