Methods and compositions for treating trinucleotide repeat disorders
First Claim
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1. An engineered zinc finger protein that modulates expression of a gene associated with a trinucleotide repeat disorder, the zinc finger protein comprising a plurality of zinc finger domains, wherein at least one zinc finger domain comprises at least one non-naturally occurring recognition helix region.
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Abstract
Disclosed herein are methods and compositions for treating trinucleotide repeat disorders.
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Citations
28 Claims
- 1. An engineered zinc finger protein that modulates expression of a gene associated with a trinucleotide repeat disorder, the zinc finger protein comprising a plurality of zinc finger domains, wherein at least one zinc finger domain comprises at least one non-naturally occurring recognition helix region.
Specification