USE OF COMPOUNDS ACTIVATING SIRT-3 FOR MIMICKING EXERCISE
3 Assignments
0 Petitions
Accused Products
Abstract
The invention relates to modulation of SIRT3 activity levels. The invention has applications for regulating metabolism and mimicking caloric restriction or exercise in a muscle cell.
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Citations
41 Claims
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1. (canceled)
- 2. A method for increasing mitochondrial biogenesis or metabolism or for boosting mitochondrial activity/endurance in a muscle cell, comprising contacting a muscle cell with an agent that increases the protein or activity level of SIRT3 in the cell.
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3. (canceled)
- 4. A method for increasing fatty acid oxidation and/or increasing glucose uptake in a muscle cell, comprising contacting a muscle cell with an agent that increases the protein or activity level of SIRT3 in the cell.
- 5. A method for decreasing reactive oxygen species (ROS) in a muscle cell, comprising contacting the muscle cell with an agent that increases the protein or activity level of SIRT3 in the cell.
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6. (canceled)
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8-9. -9. (canceled)
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19. A method for regulating skeletal muscle metabolism or skeletal muscle energy homeostasis in a subject, comprising administering to a subject in need thereof an agent that modulates the protein or activity level of SIRT3 in the subject.
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20-23. -23. (canceled)
- 24. A method for treating or preventing a disease or condition in a subject in which muscle cells would benefit from calorie restriction or exercise, comprising administering to a subject in need thereof an agent that increases the protein or activity level of SIRT3 in a muscle cell.
- 28. A method for determining whether a subject has or is likely to develop a disease or condition that is associated with a defect in muscle metabolism or muscle energy homeostasis, comprising determining the level of protein or activity of SIRT3 in a muscle cell of the subject, wherein a statistically lower level of protein or activity of SIRT3 in the cell of the subject relative to a control indicates that the subject has or is likely to develop a disease or condition that is associated with a defect in muscle metabolism or muscle energy homeostasis.
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30. A method for identifying an agent that mimics the benefits of calorie restriction or exercise in a muscle cell, comprising contacting a muscle cell with or administering into a muscle cell an agent;
- and determining whether the benefits of calorie restriction or exercise are mimicked in the cell.
- View Dependent Claims (31, 32, 33, 34)
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35-37. -37. (canceled)
Specification