N-alkylcarbonyl-amino acid ester and N-alkylcarbonyl-amino lactone compounds and their use

• US 20110082204A1
• Filed: 12/06/2010
• Published: 04/07/2011
• Est. Priority Date: 03/29/2005
• Status: Abandoned Application

• Current Assignee: Edward T. Wei
• Original Assignee: Edward T. Wei
• Inventors: Wei, Edward T.
• Application Number:
  US12/928,184
• Publication Number:
  US 20110082204A1
• Time in Patent Office: Days
• US Class Current: 514/529
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61P 1/08 for nausea, cinetosis or vertigo; Antiemetics
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 11/14 Antitussive agents
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/04 Antipruritics
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/34 Tobacco-abuse
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: C07B 2200/07 Optical isomers
• CPC Class Codes: C07C 233/63 having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
• CPC Class Codes: C07C 2601/14 The ring being saturated
• CPC Class Codes: C07D 307/33 in position 2, the oxygen atom being in its keto or unsubstituted enol form

Abstract

The present invention generally relates to refreshing, soothing, and cooling compounds that affect sensory processes. More particularly, the present invention pertains to certain N-alkylcarbonyl-amino acid ester as described herein; compositions and articles comprising such compounds; and methods of treatment, for example, methods of increasing alertness, and decreasing fatigue or sleepiness, and alleviating ocular discomforts of irritation, itch, and pain.

Claims

1. A towelette containing a compound of Formula (1):

2. A compound according to claim 1, which is (R)-2-[((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexanecarbonyl)-amino]-propionic acid methyl ester.

3. A compound according to claim 1, which is (R)-2-R(1R,2S,5R)-2-isopropyl-5-methyl-cyclohexanecarbonyl)-amino]-propionic acid ethyl ester.

4. A compound according to claim 1, which is (R)-2-[((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexanecarbonyl)-amino]-propionic acid isopropyl ester.

5. A compound according to claim 1, which is (R)-2-[((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexanecarbonyl)-amino]-acetic acid isopropyl ester.

6. The towelette as in claim 1 wherein the compound is present in the towelette at a liquid concentration of 0.2 to 2 mg/ml.

7. A method of preparing a therapeutic article of manufacture, comprising:

providing a towelette;

contacting the towelette with a compound of Formula (1);

8. Use of towelette according to claim 7 to alleviate ocular skin irritation, itch, and/or pain, and/or to increase alertness and to reduce sleepiness and fatigue.

9. A therapeutic method comprising:

contacting a towelette carrying a compound of Formula (1);

10. The method as in claim 9 wherein the therapeutically effective amount is sufficient to alleviate ocular skin irritation, itch, and/or pain, and/or to increase alertness and to reduce sleepiness and fatigue.