TREATMENT OF CLINICAL APPLICATIONS WITH NEUROMODULATION
First Claim
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1. A method of treating a disorder by non-invasive neural stimulation, the method comprising modulating the activity of the majority of a target deep-brain region, wherein the target brain region is selected from the group consisting of:
- neocortex, medial PFC, LDLPFC, RDLPFC, dorsomedial PFC, ventral PFC, VMPFC, orbitofrontal cortex (OFC), tracts between OFC and insula, cingulate genu, DACG, Pre-Gen. anterior cingulate, subgenual cingulate, posterior cingulate, striatum-DACG connections, tracts between pre-gen, anterior cingulate and insula, insula, amygdala, anterior limb of internal capsule, ventral internal capsule, target, nucleus accumbens, tract between nucleus acumbens and ventral teg., hippocampus, temporal lobes, septum, caudate (nucleus), globus pallidus, anterior nucleus of the thalamus, lateral thalamus, centromedian thalamus, thalamic subregions, subthalamic nucleus, lateral hypothalamic area nuclei, ventromedial nuclei of hypothal., cerebellum, brainstem, and pons.
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Abstract
Described herein are systems and methods for Transcranial Magnetic Stimulation (TMS) including one or more TMS electromagnets for stimulation of target deep brain regions to stimulate, enhance and/or inhibit neural activity.
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Citations
69 Claims
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1. A method of treating a disorder by non-invasive neural stimulation, the method comprising modulating the activity of the majority of a target deep-brain region, wherein the target brain region is selected from the group consisting of:
- neocortex, medial PFC, LDLPFC, RDLPFC, dorsomedial PFC, ventral PFC, VMPFC, orbitofrontal cortex (OFC), tracts between OFC and insula, cingulate genu, DACG, Pre-Gen. anterior cingulate, subgenual cingulate, posterior cingulate, striatum-DACG connections, tracts between pre-gen, anterior cingulate and insula, insula, amygdala, anterior limb of internal capsule, ventral internal capsule, target, nucleus accumbens, tract between nucleus acumbens and ventral teg., hippocampus, temporal lobes, septum, caudate (nucleus), globus pallidus, anterior nucleus of the thalamus, lateral thalamus, centromedian thalamus, thalamic subregions, subthalamic nucleus, lateral hypothalamic area nuclei, ventromedial nuclei of hypothal., cerebellum, brainstem, and pons.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of treating a disorder by non-invasive neural stimulation, the method comprising simultaneously modulating the activity of two or more target brain regions to up-regulate or down-regulate activity in the target brain region, wherein the target brain regions are selected from the group consisting of:
- NeoCortex, Medial PFC, LDLPFC, RDLPFC, Dorsomedial PFC, Ventral PFC, VMPFC, Orbitofrontal Cortex (OFC), Tracts between OFC and Insula, Cingulate Genu, DACG, Pre-Gen. Anterior Cingulate, Subgenual Cingulate, Posterior Cingulate, Striatum-DACG Connections, Tracts between Pre-Gen. Anterior Cingulate and Insula, Insula, Amygdala, Anterior Limb of Internal Capsule, Ventral Internal Capsule, Target, Nucleus Accumbens, Tract between Nucleus Acumbens and Ventral Teg., Hippocampus, Temporal Lobes, Septum, Caudate (Nucleus), Globus Pallidus, Anterior Nucleus of the Thalamus, Lateral Thalamus, Centromedian Thalamus, Thalamic Subregions, Subthalamic Nucleus, Lateral Hypothalamic Area Nuclei, Ventromedial Nuclei of Hypothal., Cerebellum, Brainstem, and Pons.
- View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
- 23. A method of treating hedonic disorders by non-invasive neural stimulation, the method comprising applying energy to modulate activity of the Orbitofrontal Cortex (OFC).
- 28. A method of treating obesity by non-invasive neural stimulation, the method comprising applying energy to modulate the activity of the Orbitofrontal Cortex (OFC).
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35. A method of treating addiction by non-invasive neural stimulation, the method comprising simultaneously applying energy to modulate the activity of two or more target brain regions selected from the group consisting of:
- the insula, the Orbitofrontal Cortex (OFC), the tracts between the OFC and the Insula, and the DACG.
- View Dependent Claims (38, 41, 44, 47, 50, 53, 56, 59)
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36. A method of treating depression by non-invasive neural stimulation, the method comprising simultaneously applying energy to modulate the activity of two or more target brain regions selected from the group consisting of:
- the LDLPFC, the RDLPFC, the DACG, and the Orbitofrontal Cortex (OFC).
- View Dependent Claims (39, 42, 45, 48, 51, 54, 57, 60)
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37. A method of treating pain by non-invasive neural stimulation, the method comprising simultaneously applying energy to modulate the activity of two or more target brain regions selected from the group consisting of:
- the Cingulate Gyms, the DACG, the Insula and the Lateral Thalamus.
- View Dependent Claims (40, 43, 46, 49, 52, 55, 58, 61)
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62. A method of treating a disorder by targeted deep-brain Transcranial Magnet Stimulation of a neuronal circuit associated with the disorder, the method comprising:
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identifying a plurality of target brain regions from a neuronal circuit associated with the neuronal disorder; aiming a plurality of TMS electromagnets at each of the target brain regions, wherein at least one of the target brain regions comprises a deep brain target; and applying power to the TMS electromagnets to modulate the activity of the target brain regions. - View Dependent Claims (63, 64, 65)
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66. A method of treating addiction by targeted deep-brain Transcranial Magnet Stimulation, the method comprising:
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targeting one or more TMS electromagnets at each of two or more of the targets selected from the list comprising;
the Orbitofrontal Cortex (OFC), the tracts between the OFC and the Insula, the DACG, the Medial PFC, the Striatum-DACG connections, the anterior limb of the internal capsule, and the Insula; andapplying power to the one or more TMS electromagnets to modulate the activity of the targeted brain regions to treat addiction.
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67. A method of treating obesity by targeted deep-brain Transcranial Magnet Stimulation, the method comprising:
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targeting one or more TMS electromagnets at each of two or more of the targets selected from the list comprising;
the Orbitofrontal Cortex (OFC), the Insula, the lateral hypothalamic area nuclei, and the ventromedial nuclei of the hypothalamus; andapplying power to the one or more TMS electromagnets to modulate the activity of the targeted brain regions to treat obesity.
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68. A method of treating pain by targeted deep-brain Transcranial Magnet Stimulation, the method comprising:
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targeting one or more TMS electromagnets at each of two or more of the targets selected from the list comprising;
the cingulate gyrus, the DACG, the Insula and the lateral thalamus; andapplying power to the one or more TMS electromagnets to modulate the activity of the targeted brain regions to treat pain.
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69. A method of treating depression by targeted deep-brain Transcranial Magnet Stimulation, the method comprising:
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targeting one or more TMS electromagnets at each of two or more of the targets selected from the list comprising;
the LDLPFC, the RDLPFC, the Orbitofrontal Cortex (OFC), and the subgenual cingulate; andapplying power to the one or more TMS electromagnets to modulate the activity of the targeted brain regions to treat depression.
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Specification