ANALYTE SENSOR APPARATUSES HAVING INTERFERENCE REJECTION MEMBRANES AND METHODS FOR MAKING AND USING THEM
First Claim
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1. An amperometric analyte sensor apparatus comprising:
- a base layer;
a conductive layer disposed on the base layer and comprising a working electrode;
an interference rejection membrane disposed on an electroactive surface of the working electrode, wherein the interference rejection membrane comprises polymers crosslinked by a hydrophilic crosslinking agent; and
an analyte sensing layer.
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Abstract
Embodiments of the invention provide amperometric analyte sensors having optimized elements such as interference rejection membranes as well as methods for making and using such sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.
58 Citations
43 Claims
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1. An amperometric analyte sensor apparatus comprising:
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a base layer; a conductive layer disposed on the base layer and comprising a working electrode; an interference rejection membrane disposed on an electroactive surface of the working electrode, wherein the interference rejection membrane comprises polymers crosslinked by a hydrophilic crosslinking agent; and an analyte sensing layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 28, 29, 30, 31, 32, 33)
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12. -27. (canceled)
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34. A method of making a sensor apparatus for implantation within a mammal comprising the steps of:
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providing a base layer; forming a conductive layer on the base layer, wherein the conductive layer includes a working electrode; forming an interference rejection membrane on the working electrode, wherein the interference rejection membrane comprises crosslinked methacrylate polymers or crosslinked primary amine polymers; forming an analyte sensing layer on the conductive layer, wherein the analyte sensing layer includes an oxidoreductase; optionally forming a protein layer on the analyte sensing layer; forming an adhesion promoting layer on the analyte sensing layer or the optional protein layer; forming an analyte modulating layer disposed on the adhesion promoting layer, wherein the analyte modulating layer includes a composition that modulates the diffusion of the analyte therethrough; and forming a cover layer disposed on at least a portion of the analyte modulating layer, wherein the cover layer further includes an aperture over at least a portion of the analyte modulating layer. - View Dependent Claims (35, 36, 37, 38)
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39. A polymeric composition comprising:
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methacrylate polymers having a molecular weight between 100 and 1000 kilodaltons, wherein the methacrylate polymers are crosslinked by a hydrophilic organofunctional dipodal alkoxysilane;
orprimary amine polymers having a molecular weight between 4 and 500 kilodaltons, wherein the primary amine polymers are crosslinked by glutaraldehyde. - View Dependent Claims (40, 41, 42, 43)
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Specification