Device for actively removing a target component from blood or lymph of a vertebrate subject

• US 20110082412A1
• Filed: 11/05/2010
• Published: 04/07/2011
• Est. Priority Date: 02/25/2009
• Status: Abandoned Application

• Current Assignee: Searete LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Ishikawa, Muriel Y., Myhrvold, Nathan P., Langer, Robert, Jung, Edward K.Y., Wood, Lowell L. JR., Hyde, Roderick A., Sweeney, Elizabeth A., Leuthardt, Eric C.
• Application Number:
  US12/927,040
• Publication Number:
  US 20110082412A1
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

Devices, systems, and methods are disclosed herein for modulating the levels of one or more target components in the blood and/or lymph of a vertebrate subject for treatment of a disease or condition in the vertebrate subject. An implantable device is provided which includes a body defining at least one lumen configured for fluid flow; at least one first reservoir in communication with at least one lumen; one or more energy sources configured to provide energy to elicit one or more signal responses associated with one or more labels that bind to one or more target components in one or more of blood fluid or lymph fluid of the vertebrate subject; one or more sensors configured to detect the one or more signal responses associated with one or more labeled target components; and one or more reactive components in communication with the at least one lumen for release responsive to the one or more sensors.

Claims

1-102. -102. (canceled)

103. A method for treating an inflammatory disease or condition in a vertebrate subject comprising:

binding one or more target components with at least one label in one or more of blood fluid or lymph fluid of the vertebrate subject;

providing energy to elicit one or more signal responses associated with one or more labeled target components;

detecting the one or more signal responses associated with the one or more labeled target components; and

providing one or more reactive components to modulate a physiological effect of the one or more target components in the one or more of blood fluid or lymph fluid of the vertebrate subject.

104. The method of claim 103, further including controlling flow of the one or more of blood fluid or lymph fluid through at least one lumen with at least one controllable flow barrier.

105. The method of claim 104, further including controlling flow of the one or more of blood fluid or lymph fluid through the at least one lumen with at least one controller in communication with one or more sensors and in communication with the at least one controllable flow barrier.

106. The method of claim 105, wherein the at least one controller includes a processor.

107. The method of claim 103, further including providing at least one first reservoir including the at least one label, wherein the at least one first reservoir is in communication with a body including at least one lumen configured for fluid flow, and the at least one first reservoir is responsive to at least one controller.

108. The method of claim 105, wherein the at least one controller is configured to control flow of the one or more of blood fluid or lymph fluid based on the one or more signal responses associated with the one or more labeled target components.

109. The method of claim 105, wherein the at least one controller is configured to control flow of the one or more of blood fluid or lymph fluid based on the label on the one or more target components.

110. The method of claim 105, wherein the at least one controller is configured to control flow of the one or more of blood fluid or lymph fluid and to control the presence of the one or more reactive components based on the label on the one or more target components.

111. The method of claim 103, further including controlling one or more energy sources with at least one controller in communication with one or more sensors, wherein the at least one controller is configured to control the one or more energy sources configured to provide the energy to elicit the one or more signal responses associated with the one or more labeled target components.

112. The method of claim 103, further including controlling release of one or more reactive components with at least one controller in communication with one or more sensors, wherein the at least one controller is configured to control release of the one or more reactive components configured to modulate the physiological effect of the one or more target components.

113. The method of claim 103, wherein one or more sensors and at least one controller are configured to control levels of the one or more target components to substantially attain a target level of the one or more target components in the one or more of blood fluid or lymph fluid of the vertebrate subject.

114. The method of claim 113, wherein the one or more sensors and the at least one controller are configured to control levels of the detected one or more target components to limit a deviation from the target level.

116. The method of claim 113, wherein the target level includes a desired concentration of the one or more target components in the one or more of blood fluid or lymph fluid.

117. The method of claim 113, wherein the target level includes a desired range of concentrations of the one or more target components in the one or more of blood fluid or lymph fluid.

118. The method of claim 113, wherein the target level includes a desired ratio of concentrations of two or more target components in the one or more of blood fluid or lymph fluid.

119. The method of claim 113, wherein the target level includes a desired ratio of levels of two or more target components in the one or more of blood fluid or lymph fluid.

121. The method of claim 107, wherein at least one of the at least one first reservoir includes a first gated mechanism responsive to one or more sensors and configured to release the one or more labels into the one or more of blood fluid or lymph fluid of the vertebrate subject.

122. The method of claim 107, wherein at least one of the at least one first reservoir includes a first gated mechanism responsive to one or more sensors and configured to expose the one or more labels to the one or more of blood fluid or lymph fluid of the vertebrate subject.

123. The method of claim 107, wherein at least one of the at least one first reservoir is disposed within the at least one lumen.

124. The method of claim 103, wherein the one or more signal responses further include one or more signal responses associated with an interior of at least one lumen.

125. The method of claim 103, wherein the one or more signal responses are associated with an interior of one or more of a blood vessel or a lymph vessel of the vertebrate subject.

126. The method of claim 103, wherein the one or more labeled target components include one or more of circulating cells or circulating emboli.

127. The method of claim 103, wherein the one or more labeled target components include one or more of tumor cells, emboli, misfolded proteins, aggregated proteins, autoimmune antibodies, infectious agents, or infected cells.

128. The method of claim 103, wherein the one or more labeled target components include one or more labeled target cells.

130. The method of claim 128, wherein one or more sensors are configured to detect the labeled target cell prior to obtaining a high resolution image of the labeled target cell.

131. The method of claim 130, wherein the one or more sensors are configured to correlate the target cell image and the detected label.

133. The method of claim 103, wherein one or more sensors are external to at least one lumen.

134. The method of claim 103, wherein one or more sensors are internal to at least one lumen.

136. The method of claim 103, further including two or more parallel lumen configured to receive the one or more target components.

137. The method of claim 136, wherein a diameter of each of the two or more parallel lumen is approximately less than two cell diameters.

142. The method of claim 103, wherein the one or more reactive components alters, arrests, disrupts, destroys, inactivates or ablates the one or more target components.

144. The method of claim 103, wherein the one or more reactive component is configured within at least one second reservoir.

146. The method of claim 144, wherein the at least one second reservoir includes a second gated mechanism responsive to one or more sensors and configured to release the one or more reactive components.

147. The method of claim 144, wherein the at least one second reservoir includes a second gated mechanism responsive to one or more sensors and configured to expose the one or more reactive components.

148. The method of claim 144, wherein the one or more reactive components include one or more reactive chemical components.

151. The method of claim 148, wherein the one or more reactive chemical components are configured to bind to at least one lumen or are configured to be released into the at least one lumen.

152. The method of claim 148, wherein the one or more reactive chemical components include one or more of a denaturing agent, degradative agent, or binding agent.

158. The method of claim 103, wherein the one or more reactive components include one or more reactive biologic components.

159. The method of claim 158, wherein the one or more reactive biologic components include one or more phagocytic cell types.

160. The method of claim 158, wherein the at least one second reservoirs include a source for producing the one or more reactive biologic components.

161. The method of claim 158, wherein the source includes at least one producer.

162. The method of claim 161, wherein the at least one producer includes at least one encapsulated cell.

164. The method of claim 162, wherein the at least one encapsulated cell includes at least one genetically-engineered cell.

168. The method of claim 158, wherein the one or more reactive biologic components include a protein, lipid micelle, liposome, polymer, catalytic antibody, or a combination thereof.

170. The method of claim 103, wherein the one or more reactive components include one or more reactive physical components.

171. The method of claim 170, wherein the one or more reactive physical components include one or more of polymers, imprinted polymers, or charged polymers.

172. The method of claim 105, wherein the one or more sensors include a biosensor, chemical sensor, physical sensor, or optical sensor.

174. The method of claim 172, wherein the one or more sensors include one or more of a recognition-based substrate, an aptamer-based substrate, an antibody-based substrate, surface plasmon resonance, genetically-modified cells, or genetically-modified cells with receptor-linked signaling.

176. The method of claim 105, wherein the one or more sensors are configured to target a device to a site having an elevated level of the target components.

181. The method of claim 152, wherein the one or more binding agents are on a matrix adapted to the one or more second reservoirs, wherein the one or more binding agents are configured to sequester at least one of the one or more target components from the one or more of blood fluid or lymph fluid.

182. The method of claim 181, wherein the one or more binding agents include one or more of antibodies, receptors, or cognates configured to bind to at least one of the one or more target components.

115. (canceled)

120. (canceled)

129. (canceled)

132. (canceled)

135. (canceled)

138-141. -141. (canceled)

143. (canceled)

145. (canceled)

149-150. -150. (canceled)

153-157. -157. (canceled)

163. (canceled)

165-167. -167. (canceled)

169. (canceled)

173. (canceled)

175. (canceled)

177-180. -180. (canceled)

183-186. -186. (canceled)

187. A method for modulating an inflammatory disease or condition in a vertebrate subject comprising:

binding one or more target components with at least one label in one or more of blood fluid or lymph fluid of the vertebrate subject;

providing energy to elicit one or more signal responses associated with one or more labeled target components;

detecting the one or more signal responses associated with the one or more labeled target components; and

providing one or more reactive chemical components to modulate a physiological effect of the one or more labeled components in the one or more of blood fluid or lymph fluid of the vertebrate subject.

190. The method of claim 187, further including controlling flow of the one or more of blood fluid or lymph fluid through at least one lumen with at least one controllable flow barrier.

191. The method of claim 190, further including controlling flow of the one or more of blood fluid or lymph fluid through the at least one lumen with at least one controller in communication with one or more sensors, and in communication with the at least one controllable flow barrier.

188-189. -189. (canceled)

192-379. -379. (canceled)