BIORESORBABLE EMBOLIZATION MICROSPHERES
First Claim
Patent Images
1. An embolic material comprising:
- a microsphere comprising a diameter between about 50 micrometers and about 2200 micrometers,wherein the microsphere comprises carboxymethyl chitosan crosslinked with carboxymethyl cellulose.
1 Assignment
0 Petitions
Accused Products
Abstract
The present disclosure is generally directed to an embolic material which, in some embodiments, may be in the form of a microsphere or a plurality of microspheres. The embolic material generally comprises carboxymethyl chitosan (CCN) crosslinked with carboxymethyl cellulose (CMC). In some embodiments, the embolic material may further comprise a therapeutic agent, such as doxorubicin.
-
Citations
44 Claims
-
1. An embolic material comprising:
-
a microsphere comprising a diameter between about 50 micrometers and about 2200 micrometers, wherein the microsphere comprises carboxymethyl chitosan crosslinked with carboxymethyl cellulose. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
-
-
9. An embolization suspension comprising:
-
a solvent; and a plurality of microspheres suspended in the solvent, wherein at least one of the plurality of microspheres comprises a diameter between about 50 micrometers and about 2200 micrometers, and wherein at least one of the plurality of microspheres comprises carboxymethyl chitosan crosslinked with carboxymethyl cellulose. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18)
-
-
19. A kit comprising:
-
a plurality of microspheres, wherein at least one of the microspheres comprises a diameter between about 50 micrometers and about 2200 micrometers, and wherein at least one of the plurality of microspheres comprises carboxymethyl chitosan crosslinked with carboxymethyl cellulose; and a syringe or vial in which the plurality of microspheres is disposed. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
-
-
31. A method of forming an embolic microsphere comprising:
-
at least partially oxidizing carboxymethyl cellulose (CMC) to form partially oxidized CMC; forming an emulsion of partially oxidized CMC, carboxymethyl chitosan (CCN), water, and an oil; and crosslinking the CCN with the CMC to form the embolic microsphere. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40)
-
-
41. A method comprising:
injecting an embolic microsphere comprising carboxymethyl chitosan crosslinked with carboxymethyl cellulose in a blood vessel of a patient to occlude an artery of the patient. - View Dependent Claims (42, 43, 44)
Specification