SELF-LUBRICATING PHARMACEUTICAL SYRINGE STOPPERS

• US 20110082430A1
• Filed: 10/01/2010
• Published: 04/07/2011
• Est. Priority Date: 10/01/2009
• Status: Active Grant

• Current Assignee: Momentive Performance Materials Incorporated (Momentive Performance Materials Holdings LLC)
• Original Assignee: Momentive Performance Materials Incorporated (Momentive Performance Materials Holdings LLC)
• Inventors: Rusinko, David M., Conzone, Samuel D., Raman, Chandrashekar
• Granted Patent: US 8,618,185 B2
• Time in Patent Office: Days
• US Class Current: 604/230
• CPC Class Codes: A61M 2005/3131 specially adapted for improving sealing or sliding
• CPC Class Codes: A61M 5/31513 Piston constructions to improve sealing or sliding
• CPC Class Codes: C10M 169/04 Mixtures of base-materials and additives
• CPC Class Codes: C10M 2201/041 Carbon; Graphite; Carbon black
• CPC Class Codes: C10M 2201/061 Carbides; Hydrides; Nitrides
• CPC Class Codes: C10M 2205/20 Natural rubber; Natural resins
• CPC Class Codes: C10M 2205/203 used as base material
• CPC Class Codes: C10M 2213/062 Polytetrafluoroethylene [PTFE]
• CPC Class Codes: C10M 2229/025 used as base material
• CPC Class Codes: C10N 2030/06 Oiliness; Film-strength; Anti-wear; Resistance to extreme pressure
• CPC Class Codes: C10N 2040/50 Medical uses

Abstract

In one aspect, a self-lubriating component is provided for a pharmaceutical packaging assembly. The self-lubricating component comprises a polymer composition and an effective amount of a lubricating additive such as, for example, boron nitride. In another aspect, a pharmaceutical packaging assembly may be provided having a surface thereof coated with a lubricating composition comprising boron nitride. The pharmaceutical packaging composition may be, for example, a pre-filled syringe comprising a body (barrel) and a plunger assembly.

Claims

1. A self-lubricating component for a pharmaceutical packaging assembly comprising a polymer composition comprising an effective amount of lubricating additive.

2. The component of claim 1 where the lubricating additive comprises one or more of:

boron nitride, graphite, polytetrafluoroethylene or any combination thereof.

3. The component of claim 1 in the form of a plunger, piston, diaphragm, or valve disc for medical equipment.

4. The component of claim 1, wherein the lubricating additive is present in an amount of from about 3 to about 50% by weight of the polymer composition.

5. The component of claim 1, wherein the lubricating additive is present in an amount of from about 3 to about 20% by weight of the polymer composition.

6. The component of claim 1, wherein the lubricating additive is present in an amount of from about 5 to about 10% by weight of the polymer composition.

7. A pharmaceutical package assembly comprising a barrel having an interior surface coated with a lubricating polymeric composition comprising a lubricating additive.

8. The pharmaceutical package assembly of claim 7, where the lubricating additive comprises one or more of:

boron nitride, graphite, polytetrafluoroethylene or any combination thereof.

9. The pharmaceutical package assembly of claim 7, wherein the lubricating additive comprises hexagonal boron nitride.

10. The pharmaceutical package assembly of claim 7, wherein the lubricating additive is present in an amount of from about 3 to about 20% by weight of the polymer composition.

11. The pharmaceutical package assembly of claim 7, wherein the lubricating additive is present in an amount of from about 5 to about 10% by weight of the polymer composition.

12. The pharmaceutical package assembly of claim 7 further comprising a plunger.

13. The pharmaceutical package assembly of claim 12, wherein the plunger is a self-lubricating component comprising a polymer composition comprising an effective amount of lubricating additive.

14. The pharmaceutical package assembly of claim 12, wherein at least a portion of a surface of the plunger is coated with a lubricating polymeric composition comprising a lubricating additive.

15. A pharmaceutical package assembly comprising a plunger having at least part of its surface coated with a lubricating polymeric composition comprising a lubricating additive.

16. The pharmaceutical package assembly of claim 15, where the lubricating additive comprises one or more of:

boron nitride, graphite, polytetrafluoroethylene or any combination thereof.

17. The pharmaceutical package assembly of claim 15, where the lubricating additive comprises hexagonal boron nitride.