Proliferation Signatures and Prognosis for Gastrointestinal Cancer
First Claim
3. A method of predicting the likelihood of long-term survival of a gastrointestinal cancer patient without the recurrence of gastrointestinal cancer, comprising determining the expression level of one or more prognostic RNA transcripts or their expression products in a gastrointestinal sample obtained from the patient, normalized against the expression level of all RNA transcripts or their products in the gastrointestinal cancer tissue sample, or of a reference set of RNA transcripts or their expression products;
- wherein the prognostic RNA transcript is the transcript of one or more genes selected from table A, Table B, Table C or Table D; and
establishing likelihood of long-term survival without gastrointestinal cancer recurrence.
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Abstract
This invention relates to methods and compositions for determining the prognosis of cancer in a patient, particularly for gastrointestinal cancer, such as gastric or colorectal cancer. Specifically, this invention relates to the use of genetic markers for the prediction of the prognosis of cancer, such as gastric or colorectal cancer, based on cell proliferation signatures. In various aspects, the invention relates to a method of predicting the likelihood of long-term survival of a cancer patient, a method of determining a treatment regime for a cancer patient, a method of preparing a personalized genomics profile for a cancer patient, among other methods as well as kits and devices for carrying out these methods.
20 Citations
45 Claims
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3. A method of predicting the likelihood of long-term survival of a gastrointestinal cancer patient without the recurrence of gastrointestinal cancer, comprising determining the expression level of one or more prognostic RNA transcripts or their expression products in a gastrointestinal sample obtained from the patient, normalized against the expression level of all RNA transcripts or their products in the gastrointestinal cancer tissue sample, or of a reference set of RNA transcripts or their expression products;
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wherein the prognostic RNA transcript is the transcript of one or more genes selected from table A, Table B, Table C or Table D; and establishing likelihood of long-term survival without gastrointestinal cancer recurrence. - View Dependent Claims (4, 5, 6, 7, 8, 9, 10, 11, 12, 45)
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- 13. An array comprising polynucleotides hybridizing to two or more genes selected from table A, Table B, Table C or Table D.
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22. A method of predicting the likelihood of long-term survival of a patient diagnosed with gastrointestinal cancer, without the recurrence of gastrointestinal cancer, comprising the steps of:
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(1) determining the expression levels of the RNA transcripts or the expression products of genes or a gene selected from table A, Table B, Table C or Table D, in a gastrointestinal cancer tissue sample obtained from the patient, normalized against the expression levels of all RNA transcripts or their expression products in the gastrointestinal cancer tissue sample, or of a reference set of RNA transcripts or their products; (2) subjecting the data obtained in step (1) to statistical analysis; and (3) determining whether the likelihood of the long-term survival has increased or decreased; and establishing the likelihood of long-term survival without gastrointestinal cancer recurrence. - View Dependent Claims (1, 2, 23, 24, 25, 26, 27, 28, 29)
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25-1. The method of claim 24, wherein the gastrointestinal tissue comprises gastrointestinal cancer cells.
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30. A prognostic method comprising:
- (a) subjecting a sample comprising gastrointestinal cancer cells obtained from a patient to quantitative analysis of the levels of RNA transcripts of at least one gene selected from any one of Table A, Table B, Table C or table D, or its product, and (b) identifying the patient as likely to have an increased likelihood of long-term survival without gastrointestinal cancer recurrence if normalized expression levels of the gene or genes, or their products, are elevated above a defined expression threshold.
- View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44)
Specification