METHODS FOR TREATING MYOFASCIAL, MUSCLE, AND/OR BACK PAIN

• US 20110086913A1
• Filed: 04/01/2010
• Published: 04/14/2011
• Est. Priority Date: 04/01/2009
• Status: Abandoned Application

• Current Assignee: Nuvo Research AG (Searchlight Pharma, Inc.)
• Original Assignee: Nuvo Research AG (Searchlight Pharma, Inc.)
• Inventors: Crockett, Andrew, Rigby, Larry, Zhang, Jie
• Application Number:
  US12/752,384
• Publication Number:
  US 20110086913A1
• Time in Patent Office: Days
• US Class Current: 514/535
• CPC Class Codes: A61F 2007/0226 adhesive, self-sticking
• CPC Class Codes: A61F 2007/0257 with a fluid impermeable layer
• CPC Class Codes: A61F 2007/0261 medicated
• CPC Class Codes: A61F 7/034 Flameless
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61K 9/7084 Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

The present disclosure is drawn to methods for treating myofascial pain, muscle pain, back pain, or combinations of these pains. Specifically, a method for treating myofascial pain, muscle pain, back pain, or combinations thereof includes the application of an analgesic system to a skin surface of a subject experiencing the pain and maintaining the analgesic system on the skin surface for a period of time of at least 30 minutes. The analgesic system applied to the skin surface can include a heating component and a local anesthetic formulation which includes at least one local anesthetic. The heating component can be capable of heating the skin surface to a temperature of 36° C. to 42° C.

Claims

1. A method for treating myofascial pain, muscle pain, back pain, or combination thereof, comprising:

applying an analgesic system to a skin surface of a subject experiencing myofascial pain, muscle pain, back pain, or combination thereof;

maintaining the analgesic system on the skin surface for a period of time of at least 30 minutes;

wherein the analgesic system comprises i) a heating component capable of heating the skin surface to a temperature of 36°

C. to 42°

C. and ii) a local anesthetic formulation including at least one local anesthetic.

2. The method of claim 1, wherein the local anesthetic formulation includes lidocaine base.

3. The method of claim 1, wherein the local anesthetic includes formulation tetracaine base.

4. The method of claim 1, wherein the local anesthetic is a eutectic mixture of lidocaine base and tetracaine base.

5. The method of claim 1, wherein the local anesthetic is a eutectic mixture of lidocaine base and tetracaine base, and the weight percentage of the eutectic mixture is more than 30% of the weight of the local anesthetic formulation.

6. The method of claim 1, wherein the local anesthetic is selected from the group of tetracaine, lidocaine, prilocaine, ropivacaine, bupivacaine, benzocaine, and combinations thereof.

7. The method of claim 1, wherein the heating component is capable of heating the skin to a temperature of 36°

C. to 42°

C. for at least 30 minutes.

8. The method of claim 1, wherein the analgesic system is maintained on the skin surface for a period of time of at least 60 minutes.

9. The method of claim 1, wherein the analgesic system is maintained on the skin surface for a period of time of at least two hours.

10. The method of claim 1, wherein the local anesthetic formulation has a skin contact region having an area of about 2 cm² to about 200 cm².

11. The method of claim 1, wherein the local anesthetic formulation has a skin contact region having an area of about 3 cm² to about 150 cm².

12. The method of claim 1, wherein the local anesthetic formulation has a skin contact region having an area of about 5 cm² to about 130 cm².

13. The method of claim 1, wherein the local anesthetic formulation has a skin contact region having an area of about 7 cm² to about 80 cm².

14. The method of claim 1, wherein the local anesthetic formulation has a skin contact region having an area of about 8 cm² and about 40 cm².

15. The method of claim 1, wherein the local anesthetic formulation has a skin contact region, said skin contact region having an area of about 8 cm² to about 13 cm².

16. The method of claim 1, wherein the local anesthetic formulation comprises at least 30% by weight of a eutectic mixture of lidocaine base and tetracaine base and the analgesic system is maintained on the skin for a period of time of at least 30 minutes, and the local anesthetic formulation has a skin contact region having an area of about 8 cm² to about 13 cm².