TRANSMUCOSAL DRUG DELIVERY DEVICE AND METHOD INCLUDING ELECTRICALLY-ACTUATED PERMEATION ENHANCEMENT
First Claim
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1. An intralumenal device for transmucosal drug delivery comprising:
- a housing configured for intralumenal deployment into a human or animal subject;
a drug-dispensing portion which contains at least one drug; and
an electrically-actuatable portion configured to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intralumenally deployed in the human or animal subject,wherein the device is operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the electrically-actuatable portion.
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Abstract
Intralumenal devices and methods are provided for transmucosal drug delivery. The device may comprise a housing configured for intralumenal deployment into a human or animal subject; a drug-dispensing portion which contains at least one drug; and an electrically-actuatable portion configured to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intralumenally deployed in the human or animal subject. The device may be operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the electrically-actuatable portion.
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Citations
27 Claims
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1. An intralumenal device for transmucosal drug delivery comprising:
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a housing configured for intralumenal deployment into a human or animal subject; a drug-dispensing portion which contains at least one drug; and an electrically-actuatable portion configured to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intralumenally deployed in the human or animal subject, wherein the device is operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the electrically-actuatable portion. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for local transmucosal delivery of a drug to a human or animal subject comprising:
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deploying a drug delivery device within a mucosal tissue lumen, the device comprising a housing and an electrically-actuatable portion; actuating the electrically-actuatable portion to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time following the insertion; and administering at least one drug through a region of the disrupted mucosal barrier. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 25)
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21. An intravaginal device for transmucosal drug delivery comprising:
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a housing configured for intravaginal deployment into a human or animal subject; an electrically-actuatable portion comprising one or more electrically-actuatable active disruption elements configured to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intralumenally inserted into the human or animal subject, and a drug dispenser comprising a drug repository containing at least one drug and a positive displacement element adapted to dispense the at least one drug from the housing into the region of the mucosal tissue disrupted by the electrically-actuatable portion. - View Dependent Claims (22, 23, 24, 26, 27)
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Specification