TRANSMUCOSAL DRUG DELIVERY DEVICE AND METHOD INCLUDING MICRONEEDLES
First Claim
1. An intralumenal device for transmucosal drug delivery comprising:
- a housing configured for intralumenal deployment into a human or animal subject;
a drug-dispensing portion which contains at least one drug; and
a plurality of microneedles extending, or being extendable from, the housing, the plurality of microneedles being configured to disrupt at least one region of a mucosal barrier adjacent the housing at a selected time after being intralumenally deployed in the human or animal subject,wherein the device is operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the plurality of microneedles.
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Accused Products
Abstract
Devices and methods for transmucosal drug delivery are provided. A device includes a housing configured for intralumenal deployment into a human or animal subject; a drug-dispensing portion which contains at least one drug; and a plurality of microneedles extending, or being extendable from, the housing, the plurality of microneedles being configured to disrupt at least one region of a mucosal barrier adjacent the housing at a selected time after being intralumenally deployed in the human or animal subject. The device is operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the plurality of microneedles.
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Citations
25 Claims
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1. An intralumenal device for transmucosal drug delivery comprising:
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a housing configured for intralumenal deployment into a human or animal subject; a drug-dispensing portion which contains at least one drug; and a plurality of microneedles extending, or being extendable from, the housing, the plurality of microneedles being configured to disrupt at least one region of a mucosal barrier adjacent the housing at a selected time after being intralumenally deployed in the human or animal subject, wherein the device is operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the plurality of microneedles. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for local transmucosal delivery of a drug to a human or animal subject comprising:
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deploying a drug delivery device within a mucosal tissue lumen; penetrating the mucosal tissue with a plurality of microneedles that extend from, or are extendable from, the drug delivery device at a selected time after the drug delivery device is deployed in the lumen; and dispensing from the device a drug such that the drug is delivered through the plurality of microneedles into the mucosal tissue or is delivered to the region of the mucosal tissue that is disrupted by the microneedles. - View Dependent Claims (14, 15, 16, 17, 18, 19)
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20. An intravaginal device for transmucosal drug delivery comprising:
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a housing configured for intravaginal deployment into a human or animal subject; a plurality of microneedles extending from, or extendable from, the housing configured to penetrate a region of the mucosal barrier adjacent to the housing at a selected time after being intravaginally deployed in the human or animal subject, and a drug dispenser comprising a drug repository containing at least one drug and a positive displacement element adapted to dispense the at least one drug from the housing through plurality of microneedles or onto the region of the mucosal tissue disrupted by the microneedles. - View Dependent Claims (21, 22, 23, 24, 25)
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Specification