DRUG-ELUTING MEDICAL DEVICES
2 Assignments
0 Petitions
Accused Products
Abstract
Composite structures composed of a device as a core structure, being a medical device or article, and a porous polymeric coat and designed capable of encapsulating bioactive agents while retaining the activity of these agents are disclosed. Further disclosed are processes of preparing such composite structures.
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Citations
63 Claims
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1-25. -25. (canceled)
- 26. A composite structure comprising a device and at least one polymeric porous coat coating at least a part of said device and encapsulating at least one bioactive agent, said coat being capable of encapsulating said at least one bioactive agent while retaining an activity of said bioactive agent and/or capable of releasing said bioactive agent in a pre-determined release rate, with the proviso that said device is not a fiber and further with the proviso that when said device is comprised of fibrous elements, said coat is not coating said fibrous elements at the contact point of intercrossing junctions of said fibrous elements in said device, such that said fibrous elements are in contact with each other in each of said junctions.
- 51. A drug-eluting stent, comprising a stent device and a polymeric porous coat coating at least a part of said stent device and encapsulating a bioactive agent, said bioactive agent is selected from the group consisting of paclitaxel, sirolimus, everolimus, zotarolimus and a farnesyl derivative having the general Formula I:
- 56. A drug-eluting mesh, comprising a mesh device and a polymeric porous coat coating at least a part of said mesh device and encapsulating a bioactive agent, said bioactive agent is an antimicrobial agent.
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60. A process of preparing a composite structure which comprises a device and a porous polymeric coat coating at least a part of said device, wherein the coat comprises at least one bioactive agent encapsulated therein and/or applied thereon, the process comprising:
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contacting said device and an emulsion containing an aqueous solution and an organic solution, said organic solution containing at least one second polymer and said emulsion further containing said at least one bioactive agent either within said aqueous solution or within said organic solution, to thereby obtain said device having a layer of said emulsion applied on at least a part thereof; and freeze-drying said device having said layer applied thereon, thereby obtaining the composite structure; with the proviso that said device is not a fiber and further with the proviso that when said device is comprised of fibrous elements, said layer of said emulsion is not applied on said fibrous elements at the contact point of intercrossing junctions of said fibrous elements in said device, such that said fibrous elements are in contact with each other in each of said junctions. - View Dependent Claims (61, 62, 63)
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Specification