IMPLANT DEVICES HAVING VARYING BIOACTIVE AGENT LOADING CONFIGURATIONS

• US 20110091518A1
• Filed: 09/22/2010
• Published: 04/21/2011
• Est. Priority Date: 09/22/2009
• Status: Abandoned Application

• Current Assignee: Evonik Corporation (Rag-Stiftung)
• Original Assignee: Evonik Corporation (Rag-Stiftung)
• Inventors: Biggs, Danielle
• Application Number:
  US12/887,893
• Publication Number:
  US 20110091518A1
• Time in Patent Office: Days
• US Class Current: 424/426
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/0092 Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes

Abstract

Described herein are implant devices comprising various configurations of bioactive agent loading which can be selected and used to tailor a particular bioactive agent release profile from the implant device.

Claims

1. An implant device comprising a biocompatible or biodegradable longitudinal body comprising a longitudinal surface and a proximal and distal end surface;

wherein the implant device comprises a bioactive agent coated onto one or more surfaces and not dissolved or dispersed within the longitudinal body.

2. The implant device of claim 1, wherein the implant device comprises a bioactive agent coated only onto the proximal and/or distal end surface.

3. The implant device of claim 1, wherein the longitudinal body comprises poly(lactide), poly(glycolide), poly(caprolactone), poly(lactide-co-glycolide), or an admixture, combination, or copolymer thereof.

4. An implant device comprising a longitudinal body having an inner core comprising a longitudinal surface surrounded by a polymeric sheath and exposed proximal and distal end surfaces that are not surrounded by the polymeric sheath;

wherein the polymeric sheath comprises a longitudinal outer surface which is substantially coextensive with the longitudinal core surface; and

wherein at least one of the inner core or the polymeric membrane sheath comprises a biodegradable polymer having a bioactive agent dissolved or dispersed therein.

5. The implant device of claim 4, wherein both the inner core and the polymeric membrane sheath comprise a bioactive agent dissolved or dispersed therein.

6. The implant device of claim 4, wherein both the inner core and the polymeric membrane sheath comprise a bioactive agent dissolved or dispersed therein;

and wherein the inner core and the polymeric membrane sheath comprise different concentrations of bioactive agent.

7. The implant device of claim 4, wherein one or more of the proximal end surface, distal end surface, or longitudinal outer surface is coated with a biocompatible or biodegradable coating polymer.

8. The implant device of claim 4, wherein one or more of the proximal end surface, distal end surface, or longitudinal outer surface is coated with a bioactive agent that is the same or different than the bioactive agent dissolved or dispersed in the inner core and/or the polymeric membrane sheath.

9. The implant device of claim 4, wherein the polymeric membrane sheath does not comprise a bioactive agent dissolved or dispersed therein.

10. The implant device of claim 4, wherein the polymeric sheath comprises a polymer that creates a barrier membrane around the inner core.

11. The implant device of claim 4, wherein the longitudinal body comprises poly(lactide), poly(glycolide), poly(caprolactone), poly(lactide-co-glycolide), or an admixture, combination, or copolymer thereof.