Modulating Drug Release Rate By Controlling The Kinetics Of The pH Transition In Hydrogels
First Claim
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1. A method comprising:
- contacting a first hydrogel precursor with a first buffer;
contacting a second hydrogel precursor with a second buffer;
adding a bioactive agent to the first hydrogel precursor, the second hydrogel precursor, or both; and
contacting tissue with the first hydrogel precursor and the second hydrogel precursor,wherein the first hydrogel precursor and second hydrogel precursor form a hydrogel upon contact, and wherein the bioactive agent has a pKa between the initial pH of the hydrogel at formation, and the physiologic pH.
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Abstract
Methods and compositions relate to modulating the release profile of drug molecules from a hydrogel by controlling the kinetics of the pH transition of the hydrogel. The hydrogel is formed by in situ polymerization and includes a drug molecule having a pKa between the pH of the formed hydrogel and the physiologic environment in which the hydrogel is placed.
79 Citations
25 Claims
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1. A method comprising:
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contacting a first hydrogel precursor with a first buffer; contacting a second hydrogel precursor with a second buffer; adding a bioactive agent to the first hydrogel precursor, the second hydrogel precursor, or both; and contacting tissue with the first hydrogel precursor and the second hydrogel precursor, wherein the first hydrogel precursor and second hydrogel precursor form a hydrogel upon contact, and wherein the bioactive agent has a pKa between the initial pH of the hydrogel at formation, and the physiologic pH. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A kit for producing a hydrogel comprising:
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a first precursor; a second precursor; a first buffer for the first precursor; a second buffer for the second precursor; a bioactive agent; and an applicator for substantially simultaneously delivering the bioactive agent, and the first and second precursors.
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14. A hydrogel comprising:
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a first precursor combined with a first buffer; a second precursor combined with a second buffer; a bioactive agent; and wherein the pKa of the bioactive agent is greater than the pH of the hydrogel, and wherein the pH of the first buffer, the second buffer, or both, is selected to increase or decrease the release of the bioactive agent from the hydrogel. - View Dependent Claims (15, 16, 17, 18, 19)
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20. A hydrogel comprising:
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a first precursor combined with a first buffer; a second precursor combined with a second buffer; a bioactive agent; and wherein the pKa of the bioactive agent is less than the pH of the hydrogel, and the pH of the first buffer, the second buffer, or both, is selected to increase or decrease the release of the bioactive agent from the hydrogel. - View Dependent Claims (21, 22, 23, 24, 25)
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Specification