ORALLY-DISINTERGRATING SOLID PREPARATION
First Claim
1. An orally-disintegrating solid preparation comprising fine granules showing controlled release of a pharmaceutically active ingredient, which has a coating layer comprising a polymer affording a casting film having an elongation at break of about 100%-about 700%.
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Abstract
The present invention provides an orally-disintegrating solid preparation such as a tablet produced by tabletting fine granules showing controlled release of a pharmaceutically active ingredient and an additive, and the like, and the orally-disintegrating solid preparation containing fine granules coated with a coating layer containing a polymer affording a casting film having an elongation at break of about 100-about 700%. With the preparation, breakage of fine granules during tabletting can be suppressed in the production of an orally-disintegrating solid preparation containing fine granules showing controlled release of a pharmaceutically active ingredient.
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Citations
41 Claims
- 1. An orally-disintegrating solid preparation comprising fine granules showing controlled release of a pharmaceutically active ingredient, which has a coating layer comprising a polymer affording a casting film having an elongation at break of about 100%-about 700%.
- 23. An orally-disintegrating solid preparation comprising (1) fine granules A showing controlled release of a pharmaceutically active ingredient and (2) fine granules B with a different release rate of a pharmaceutically active ingredient from that of the fine granules of (1), which has a coating layer comprising a polymer affording a casting film having an elongation at break of about 100%-about 700%.
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39. A method of suppressing breakage of fine granules showing controlled release of a pharmaceutically active ingredient, which are comprised in an orally-disintegrating tablet obtained by tabletting the fine granules and an additive, which method comprises, during production of the tablet, coating the fine granules with a coating layer comprising a polymer affording a casting film having an elongation at break of about 100-about 700%.
Specification