MULTISITE BIOSENSOR AND ASSOCIATED METHOD
First Claim
1. A method of detecting a biomarker comprising:
- identifying a quantity of biomolecule types in a sample;
exposing the sample to a plurality of test sites, wherein the number of test sites in the plurality of test sites is equal to or greater than the identified quantity of biomolecule types;
establishing, for each of the plurality of test sites, a respective test environment, wherein the test environment for each of the plurality of test sites is different from the test environment for each of the other of the plurality of test sites;
obtaining a detection signal associated with each of the plurality of test sites; and
determining the concentration of one of the biomolecule types based upon the obtained detection signals.
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Abstract
A method of detecting a biomarker in one embodiment includes identifying a quantity of biomolecule types in a sample, exposing the sample to a plurality of test sites, wherein the number of test sites in the plurality of test sites is equal to or greater than the identified quantity of biomolecule types, establishing, for each of the plurality of test sites, a respective test environment, wherein the test environment for each of the plurality of test sites is different from the test environment for each of the other of the plurality of test sites, obtaining a detection signal associated with each of the plurality of test sites, and determining the concentration of one of the biomolecule types based upon the obtained detection signals.
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Citations
20 Claims
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1. A method of detecting a biomarker comprising:
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identifying a quantity of biomolecule types in a sample; exposing the sample to a plurality of test sites, wherein the number of test sites in the plurality of test sites is equal to or greater than the identified quantity of biomolecule types; establishing, for each of the plurality of test sites, a respective test environment, wherein the test environment for each of the plurality of test sites is different from the test environment for each of the other of the plurality of test sites; obtaining a detection signal associated with each of the plurality of test sites; and determining the concentration of one of the biomolecule types based upon the obtained detection signals. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of determining a concentration of a biomarker in a sample comprising:
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identifying a quantity of detection signal contributors for a plurality of detection signals, wherein at least one of the detection signal contributors is a molecule of interest; exposing a sample to a plurality of test sites, wherein the number of test sites in the plurality of test sites is equal to or greater than the identified quantity of detection signal contributors; establishing, for each of the plurality of test sites, a respective test environment, wherein the test environment for each of the plurality of test sites is different from the test environment for each of the other of the plurality of test sites; obtaining a respective one of the plurality of detection signals from each of the plurality of test sites; and determining the concentration of a biomolecule of interest based upon the obtained plurality of detection signals. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
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Specification