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DETECTION OF PLURALITY OF TARGETS IN BIOLOGICAL SAMPLES

  • US 20110092381A1
  • Filed: 10/21/2009
  • Published: 04/21/2011
  • Est. Priority Date: 10/21/2009
  • Status: Active Grant
First Claim
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1. A method of detecting a plurality of targets in a biological sample, comprising:

  • (a) contacting the biological sample with a plurality of target-binding probes to form a plurality of target-bound probes;

    (b) covalently attaching at least one of the target-bound probes to the biological sample;

    (c) observing a first set of signals from a first set of the plurality of target-bound probes;

    (d) modifying the observed signals;

    (e) generating a second set of signals from a second set of the plurality of target-bound probes; and

    (f) observing the second set of signals.

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