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METHODS OF DETECTING TARGETS ON AN ARRAY

  • US 20110092389A1
  • Filed: 12/17/2010
  • Published: 04/21/2011
  • Est. Priority Date: 02/10/2000
  • Status: Active Grant
First Claim
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1. A method of detecting a target analyte in a biological sample, comprising:

  • a) providing a composite array comprising;

    a substrate having a surface;

    a first and a second assay location on said surface, wherein said assay locations comprise a population of microspheres, and wherein said microspheres comprise bioactive agents; and

    a gasket separating said first assay location from said second assay location;

    b) sealing said first and second assay locations thereby forming separately sealed hybridization chambers, said hybridization chambers each comprising a plurality of wells, wherein said microspheres are retained within said wells;

    c) adding said biological sample to said first assay location under conditions sufficient to allow said target analyte to bind to said bioactive agents; and

    d) detecting the binding of said bioactive agents to said target analyte, wherein the binding of said bioactive agents to said target analyte indicates the presence of said target analyte in said biological sample.

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