ENERGETIC MODULATION OF NERVES
First Claim
Patent Images
1. A method of treatment, comprising:
- placing an energy source outside a patient;
operating the energy source so that an energy delivery path of the energy source is aimed towards a nerve inside the patient, wherein the nerve is a part of an autonomic nervous system; and
using the energy source to deliver treatment energy from outside the patient to the nerve located inside the patient to treat the nerve.
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Abstract
In some examples, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some examples, different types of energy sources are utilized singly or combined with one another. In some examples, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents or the agents are enhanced by the energy sources.
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Citations
148 Claims
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1. A method of treatment, comprising:
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placing an energy source outside a patient; operating the energy source so that an energy delivery path of the energy source is aimed towards a nerve inside the patient, wherein the nerve is a part of an autonomic nervous system; and using the energy source to deliver treatment energy from outside the patient to the nerve located inside the patient to treat the nerve. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59)
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60. A system for treatment, comprising:
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an energy source for placement outside a patient; wherein the energy source is configured to aim an energy delivery path towards a nerve that is a part of an autonomic nervous system inside the patient; and wherein the energy source is configured to deliver treatment energy from outside the patient to the nerve located inside the patient to treat the nerve. - View Dependent Claims (61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87)
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88. A system to deliver energy from a position outside a skin of a patient to a nerve surrounding a blood vessel inside the patient, comprising:
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a processor configured to receive image signal, and determine a three dimensional coordinate of a blood vessel based on the image signal; and an energy source configured to deliver energy from the position outside the skin of the patient to the nerve surrounding the blood vessel; wherein the processor is also configured to control the energy source based on the determined coordinate. - View Dependent Claims (89, 90, 91, 92, 93, 94, 95)
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96. A system to deliver energy from a position outside a skin of a patient to a nerve surrounding a blood vessel comprising:
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a fiducial for placement inside the blood vessel; a detection device to detect the fiducial inside the blood vessel; a processor configured to determine a three dimensional coordinate of the detected fiducial; and an energy source configured to transmit energy through the skin and to focus the energy at the region of the blood vessel; wherein the processor is configured to operate the energy source based on the determined three dimensional coordinate of the fiducial, and information regarding the blood vessel. - View Dependent Claims (97, 98, 99, 100, 101)
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102. A method to treat hypertension in a patient comprising:
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obtaining an imaging signal from a blood vessel in the patient; planning a delivery of energy to a wall of the blood vessel; and delivering energy from outside a skin of the patient to an autonomic nerve surrounding the blood vessel. - View Dependent Claims (103, 104, 105)
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106. A system to modulate an autonomic nerve in a patient utilizing transcutaneous energy delivery, the system comprising:
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a processor comprising; an input for receiving information regarding energy and power to be delivered to a treatment region containing the nerve; and an output for outputting a signal; wherein the processor is configured to determine a position of a reference target from outside the patient to localize the nerve relative to the reference target; a therapeutic energy device comprising; a transducer for delivering energy from outside the patient; a controller to control an aiming of the transducer based at least in part on the signal from the processor; and an imaging system coupled to the processor or the therapeutic energy device. - View Dependent Claims (107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118)
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119. A method to deliver energy from a position outside the skin of a patient to a nerve surrounding a blood vessel, comprising:
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placing a device inferior to ribs, superior to an iliac crest, and lateral to a spine; using the device to maintain an energy delivery system at a desired position relative to the patient so that the energy delivery system can deliver energy through the skin without traversing bone. - View Dependent Claims (120)
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121. A device for use in a system to deliver focused ultrasound energy from a position outside a skin of a patient to a nerve surrounding a blood vessel, comprising:
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a positioning device configured to maintain an energy delivery system at a desired position relative to the patient so that the energy delivery system can deliver energy through the skin without traversing bone; wherein the positioning device is configured to be placed inferior to ribs, superior to an iliac crest, and lateral to a spine. - View Dependent Claims (122, 123)
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124. A system for treatment, comprising:
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a treatment device configured to deliver energy from outside a patient to a nerve inside the patient; a catheter configured for placement inside a vessel surrounded by the nerve, the catheter configured to transmit a signal; and a processor configured to receive the signal and determine a reference position in the vessel; wherein the treatment device is configured deliver the energy to the nerve based on the determined reference position. - View Dependent Claims (125)
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126. A method of inhibiting the function of a nerve traveling with an artery comprising:
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providing an external imaging modality to determine the location of the artery of a patient; placing the artery in a first three dimensional coordinate reference based on the imaging; placing or associating a therapeutic energy generation source in the first three dimensional coordinate reference frame; modeling the delivery of energy to the adventitial region of the artery or a region adjacent to the artery where a nerve travels; delivering therapeutic energy from the therapeutic energy source, from at least two different angles, through the skin of a patient, to intersect at the artery or the region adjacent to the artery; and, at least partially inhibiting the function of the nerve traveling with the artery. - View Dependent Claims (127, 128, 129, 130, 131, 132, 133, 134, 135, 136)
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137. A system to inhibit the function of a nerve traveling with a renal artery comprising:
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a detector to determine the location of the renal artery and renal nerve from a position external to a patient; an ultrasound component to deliver therapeutic energy through the skin from at least two directions to the nerve surrounding the renal artery; a modeling algorithm comprising an input and an output, said input to the modeling algorithm comprising a three dimensional coordinate space containing a therapeutic energy source and the position of the renal artery in the three dimensional coordinate space; and
,said output from the modeling algorithm comprising;
the direction and energy level of the ultrasound component;a fiducial, locatable from a position outside a patient, adapted to be temporarily placed in the artery of the patient and communicate with the detector to determine the location of the renal artery in a three dimensional reference frame, the information regarding the location transmittable as the input to the model. - View Dependent Claims (138, 139, 140, 141, 142, 143, 144)
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145. A method to stimulate or inhibit the function of a nerve traveling to or from the kidney comprising:
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a. Identifying an acoustic window at the posterior region of a patient in which the renal arteries can be visualized; b. transmitting a first energy through the skin of a patient from the posterior region of the patient; c. imaging an arterial region using the first transmitted energy; d. applying a second transmitted energy to the arterial adventitia by coupling the imaging and the second transmitted energy. - View Dependent Claims (146)
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147. A method to locate the position of a blood vessel in the body of a patient comprising:
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applying a first wave of ultrasound, from a first direction, to a region of a blood vessel from outside of the patient and detecting its return signal; comparing the applied first wave and its return signal; simultaneously, or sequentially, applying a second wave of ultrasound from a second direction to the blood vessel and detecting a its return signal; integrating the return signals from the first wave and the return signals from the second wave to determine the position, in a three dimensional coordinate reference, of the blood vessel. - View Dependent Claims (148)
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Specification