IN VIVO MICRO-INVASIVE INVESTIGATION DEVICE INCLUDING A METAL GUIDE
First Claim
1. An analysis device comprising a system for a micro-invasive and/or micro-sampling investigation of a substrate, said system comprising at least one metal guide including:
- an Ea extremity the surface of which is structured so as to define at least a series of wells to which is directly coupled at least one reactive group specific to said substrate, said Ea extremity being perforating, andanother Em extremity intended for handling said metal guide.
1 Assignment
0 Petitions
Accused Products
Abstract
The invention relates to an analysis device, wherein said system includes at least one metal guide at one end of which is provided at least one series of pits to which are directly coupled reagents specific to a substrate, said end being a perforating one, while the other end is intended for controlling said guide and is optionally associated with a suction system. The guide may be inserted into a protection system that is removable at the level of the functionalised end, up to the micro-analysis and/or micro-sampling site, and/or into a medical instrument having an inner channel in which said guide may slide. The present invention also relates to the use of such a device for making a tool for diagnosing cancer, an inflammation, an infection, a neurodegenerative disease or a graft rejection in a patient, preferably by transparietal delivery. The invention further relates to a method for the ex vivo analysis of a substrate using such a device.
6 Citations
27 Claims
-
1. An analysis device comprising a system for a micro-invasive and/or micro-sampling investigation of a substrate, said system comprising at least one metal guide including:
-
an Ea extremity the surface of which is structured so as to define at least a series of wells to which is directly coupled at least one reactive group specific to said substrate, said Ea extremity being perforating, and another Em extremity intended for handling said metal guide. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
-
-
16. A tool intended for diagnosing a cancer, an inflammation, an infection, a graft rejection or a neurodegenerative pathology such as Alzheimer'"'"'s disease, Parkinson'"'"'s disease or an amyotrophic lateral sclerosis, the tool manufactured using an analysis device for manufacturing the tool, the analysis device comprising a system for a micro-invasive and/or micro-sampling investigation of a substrate, said system comprising at least one metal guide including:
-
an Ea extremity the surface of which is structured so as to define at least a series of wells to which is directly coupled at least one reactive group specific to said substrate, said Ea extremity being perforating, and another Em extremity intended for handling said metal guide. - View Dependent Claims (17, 18, 19, 20, 21)
-
-
22. A method for detecting ex-vivo a substrate existing in a tissue or an organ, comprising:
-
providing a device comprising a system for a micro-invasive and/or micro-sampling investigation of a substrate, said system comprising at least one metal guide including; an Ea extremity the surface of which is structured so as to define at least a series of wells to which is directly coupled at least one reactive group specific to said substrate, said Ea extremity being perforating, and another Em extremity intended for handling said metal guide; a) incubation of the functionalised Ea extremity of the device with a solution comprising at least one detection agent specific to said substrate when said extremity is in contact with said tissue or organ to be examined; and b) detection of said substrate. - View Dependent Claims (23, 24, 25, 26, 27)
-
Specification