RADIOLABELING METHOD USING MULTIVALENT GLYCOLIGANDS AS HEPATIC RECEPTOR IMAGING AGENT
First Claim
1. A radiolabeling method using a multivalent glycoligand as hepatic receptor imaging agent, formed by reacting a multivalent glycoligand-DTPA derivative with In-111 at room temperature or under heating for 30 min.
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Abstract
A radiolabeling method using a multivalent glycoligand as hepatic receptor imaging agent is provided. The multivalent glycoligand-DTPA derivatives (In-111-DTPA-hexa lactoside and In-111-DTPA-tri-galactosamine glycoside) labeled with In-111 are used as hepatic receptor imaging agent. The effects of imaging of a hepatic receptor in different species are evaluated, the lowest specific radioactivity values of hepatic receptor imaging required in different species are discovered. Since the specificity of the human ASGPR closely resembles that of the mouse. This kind of radiolabelling method, agent and related study about specific radioactivity could be used in clinical trial in the future.
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Citations
9 Claims
- 1. A radiolabeling method using a multivalent glycoligand as hepatic receptor imaging agent, formed by reacting a multivalent glycoligand-DTPA derivative with In-111 at room temperature or under heating for 30 min.
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