Methods for detecting atrial fibrillation and related conditions
First Claim
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1. A method of detecting a disorder associated with a cardiac arrhythmia in a subject having said disorder comprising measuring the amount of an apelin polypeptide, or a fragment thereof, in the plasma of the subject, and determining that the amount is reduced in comparison to that of a control subject, thereby detecting said disorder.
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Abstract
Methods for detecting disorders associated with atrial fibrillation, and, thus, at risk for stroke and/or heart failure) in a subject based on a monitoring plasma levels of apelin are provided. Diagnostic compositions for the detection of such disorders are additionally provided.
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23 Claims
- 1. A method of detecting a disorder associated with a cardiac arrhythmia in a subject having said disorder comprising measuring the amount of an apelin polypeptide, or a fragment thereof, in the plasma of the subject, and determining that the amount is reduced in comparison to that of a control subject, thereby detecting said disorder.
- 6. A method of detecting a disorder associated with a cardiac arrhythmia in a subject having said disorder comprising measuring the amount of an apelin nucleotide sequence in the circulating cells or plasma of the subject, and determining that the amount is reduced in comparison to that of a control subject, thereby detecting said disorder.
- 11. A method of identifying a subject having or at risk of having atrial fibrillation comprising measuring the amount of an apelin polypeptide, or a fragment thereof, in the circulating cells or plasma or a preparation thereof of the subject, and determining that the amount is reduced in comparison to that of a control subject, thereby identifying the subject having or at risk of having atrial fibrillation.
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22. An article of manufacture for diagnosing a predisposition for atrial fibrillation in a subject comprising packaging material, a diagnostic kit, and instructions with the packaging material, wherein the diagnostic kit comprises an immunological agent that binds with specificity to the apelin polypeptide, or a fragment thereof, to form a bound complex and a means for measuring the quantity of bound complexes in a biological sample or a preparation thereof of a subject, wherein the quantity of bound complex as compared to a normal control is indicative for a predisposition for atrial fibrillation, and wherein the instructions indicate that the diagnostic kit can be used to diagnose a predisposition for atrial fibrillation in the subject.
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