ASSESSING MEDICAL CONDITIONS BASED ON VENOUS OXYGEN SATURATION AND HEMATOCRIT INFORMATION

• US 20110098546A1
• Filed: 12/22/2010
• Published: 04/28/2011
• Est. Priority Date: 02/08/2008
• Status: Abandoned Application

• Current Assignee: Gene A. Bornzin, John W. Poore, Keith Victorine, Kyungmoo Ryu, Taraneh Ghaffari Farazi, Xiaoyi Min, Yelena Nabutovsky
• Original Assignee: Gene A. Bornzin, John W. Poore, Keith Victorine, Kyungmoo Ryu, Taraneh Ghaffari Farazi, Xiaoyi Min, Yelena Nabutovsky
• Inventors: Poore, John W., Min, Xiaoyi, Ryu, Kyungmoo, Bornzin, Gene A., Farazi, Taraneh Ghaffari, Nabutovsky, Yelena, Victorine, Keith
• Application Number:
  US12/976,493
• Publication Number:
  US 20110098546A1
• Time in Patent Office: Days
• US Class Current: 600/325
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/14535 for measuring haematocrit
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/363 Detecting tachycardia or bradycardia
• CPC Class Codes: A61B 5/7285 for synchronising or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal A61B6/5205, A61B6/541, A61B8/5207, A61B8/543 take precedence
• CPC Class Codes: A61N 1/36557 controlled by chemical substances in blood
• CPC Class Codes: A61N 1/36564 controlled by blood pressure
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

Methods for assessing, diagnosing and treating medical conditions using SvO₂ and hematocrit measurements alone, or in combination with other measurements related to cardiac activity are provided. These includes methods for distinguishing true anemia from diluted anemia, methods for anemia detection, methods for measuring disease progression based on anemia trending, methods for managing therapy delivery, methods for managing heart failure drug therapies, methods for cardiac output optimization based on SvO₂, methods for cardiac resynchronization therapy lead placement, method for detection of heart failure decompensation, and methods to monitor and treat systolic versus diastolic heart failure are provided.

Claims

1. A method to differentiate systolic and diastolic heart failure, comprising

(a) receiving cardiac output measurements from an implantable SvO2 sensor;

(b) receiving pressure measurements from a heart pressure sensor;

(c) determining hemodynamics based on the cardiac output measurements and the pressure measurements; and

(d) differentiating systolic and diastolic heart failure based on the hemodynamics.

2. The method of claim 1, further comprising trending SvO2 and hematrocrit levels as heart failure progresses, wherein trending data provides a status of fluid overload prior to pulmonary edema, wherein an initial phase of increased pressure and fluid is detected by a decrease in hematocrit.

3. The method of claim 1, wherein the heart pressure sensor is a left ventricular end-diastolic pressure sensor or a left atrial pressure sensor.