METHODS AND APPARATUSES FOR DETECTING ANALYTES

• US 20110098590A1
• Filed: 10/26/2010
• Published: 04/28/2011
• Est. Priority Date: 10/26/2009
• Status: Abandoned Application

• Current Assignee: Pulse Health LLC
• Original Assignee: Pulse Health LLC
• Inventors: Hunt, John, Urman, David, Mastin, Stephen H., Garbutt, Ian, Marsh, Chris, Spiegel, Wes
• Application Number:
  US12/912,526
• Publication Number:
  US 20110098590A1
• Time in Patent Office: Days
• US Class Current: 600/532
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/097 Devices for facilitating collection of breath or for directing breath into or through measuring devices

Abstract

An apparatus for measuring a quantity of an analyte, such as an aldehyde, contained in a breath sample includes a breath collection device and a measurement device. The breath collection device includes a breath inlet area, a breath outlet area, and a reaction chamber. The reaction chamber can include a reagent that is colorimetrically reactive with one or more aldehydes. The measurement device includes a light emitting device and a light measuring device and is configured to provide a quantitative value indicative of the amount of aldehydes present in the breath sample.

Claims

1. An apparatus for measuring a quantity of an analyte contained in a breath sample, the apparatus comprising:

a breath collection device comprising a breath inlet area, a breath outlet area, and a reaction chamber, the reaction chamber including a reagent that is colorimetrically reactive with the analyte; and

a measurement device comprising a light emitting device and a light measuring device, the measurement device being configured to receive the breath collection device so that the reagent is positioned to receive light from the light emitting device and reflect at least a portion of the received light to the light measuring device.

2. The apparatus of claim 1, wherein the analyte comprises one or more aldehydes.

3. The apparatus of claim 1, wherein the light emitting device comprises a plurality of LEDs.

4. The apparatus of claim 3, wherein each of the plurality of LEDs emits light at the same wavelength.

5. The apparatus of claim 3, wherein each of the plurality of LEDs emits light at a different wavelength.

6. The apparatus of claim 5, comprising:

a first LED that emits light in a range absorbed by the reagent that corresponds, at least in part, to a reactivity of the reagent to moisture; and

a second LED that emits light in a range absorbed by the reagent that corresponds, at least in part, to a reactivity of the reagent to the analyte.

7. The apparatus of 1, further comprising a value generating device comprising an algorithm that generates a quantitative value based on one or colorimetric measurements taken by the measurement device on the reagent.

8. The apparatus of 7, further comprising a moisture reactivity measuring device, wherein the algorithm is configured to normalize the colorimetric measurements based on a measurement of an amount of moisture contained in the reagent.

9. The apparatus of claim 8, wherein the moisture reactivity measuring device comprises an LED that emits light in a range absorbed by the reagent that corresponds, at least in part, to a reactivity of the reagent to moisture.

10. A breath collection device comprising:

a tubular outer member having a first end portion and a second end portion,

a breath inlet area having a first porous plug member positioned in the tubular outer member at the first end portion;

a breath outlet area having a second porous plug member positioned in the tubular outer member at the second end portion, the second porous plug member having a first cylindrical portion with a first diameter and a second cylindrical portion with a second diameter, the second diameter being smaller than the first diameter; and

a reaction chamber within the tubular outer member and located between the first and second porous plug members, the reaction chamber including a reagent that is colorimetrically reactive with one or more substances contained in the exhaled breath of a test subject,

wherein the second cylindrical portion extends from the first cylindrical portion towards the first porous plug member.

11. The device of claim 10, further comprising a breakable container, the reagent being at least initially held within the container.

12. The device of claim 11, wherein the container comprises a wrap extending around at least a portion of the container to reduce the amount of broken pieces of container that result when the container is broken and the reagent released.

13. The device of claim 12, wherein the wrap extends around at least 70% of the container.

14. The device of claim 13, wherein the wrap extends around between about 85% and 95% of the container.

15. The device of claim 14, further comprising a hood member, the hood member comprising a breath receiving portion and a breath outflow portion,

wherein the breath outflow portion is configured to be removably coupled to the first end portion of the tubular outer member.

16. The device of claim 15, wherein the breath receiving portion and the breath outflow portion are configured at an angle of about 70 and 110 degrees relative to one another.

17. An apparatus for measuring a quantity of an analyte contained in a breath sample, the apparatus comprising:

a breath collection device comprising a breath inlet area, a breath outlet area, and a reaction chamber, the reaction chamber including a reagent that is colorimetrically reactive with the analyte;

a measurement device comprising a light emitting device and a light measuring device, the measurement device being configured to receive the breath collection device so that the reagent is positioned to receive light from the light emitting device and reflect at least a portion of the received light to the light measuring device, the light measuring device being configured to take a plurality of reflectance measurements over a predetermined time period for at least two wavelength regions; and

a measurement selection device configured to select one or more measurements taken by the measurement device to determine the quantity of the analyte, the measurement selection device being configured to select the one or more measurements based on a determination of a rate of change of reflectance of at least one of the at least two wavelength regions.

18. The apparatus of claim 17, wherein the at least two wavelength regions comprise a first region including wavelengths between about 400 nm and 450 nm and a second region including wavelengths between about 550 nm and 600 nm.

19. The apparatus of claim 18, wherein the rate of change of reflectance is determined in the second region.