DEVICE DELIVERING MEDICINES BY TRANSPALPEBRAL ELECTROPHORESIS

• US 20110098632A1
• Filed: 10/27/2010
• Published: 04/28/2011
• Est. Priority Date: 10/12/2001
• Status: Active Grant

• Current Assignee: EyeGate Pharma S.A.S. (Kiora Pharmaceuticals Incorporated)
• Original Assignee: EyeGate Pharma S.A.S. (Kiora Pharmaceuticals Incorporated)
• Inventors: Behar-Cohen, Francine, Roy, Pierre
• Granted Patent: US 8,771,256 B2
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61N 1/0412 Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
• CPC Class Codes: A61N 1/0436 Material of the electrode
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0448 Drug reservoir
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428

Abstract

The invention concerns a device for ocular application of an active principle (1) comprising a main electrode (2) including an insulating layer, an adhesive layer designed to bind the insulating layer to a conductive layer, characterized in that the main electrode comprises a zone (21, 22) designed to be urged into contact with an eyelid.

Claims

1-14. -14. (canceled)

15. A system for ocular application of an active substance, comprising:

an insert disposed between an eyelid and an eyeball, the insert comprising an active substance; and

a main electrode disposed on an outer surface of the eyelid, the main electrode comprising a functional area configured to deliver current through the eyelid, the insert, and into the eyeball.

16. The system of claim 15, wherein the insert comprises a functional area and a non-functional central area, the functional area circumferentially surrounding the nonfunctional central area and containing the active substance.

17. The system of claim 16, wherein the functional area covers substantially the sclera of an eyeball and the non-functional central area covers the cornea of the eyeball.

18. A method for ocular application of an active substance, the method comprising:

disposing a main electrode on an eyelid of a patient;

disposing a return electrode on a tissue of the patient relative to the eyelid; and

applying an electrical current circulating between the main electrode and the return electrode thereby allowing the active substance to penetrate the sclera of an eyeball of the patient via the applied electrical current.

19. A method according to claim 18, further comprising disposing an insert on the eyelid, the insert comprising the active substance and being disposed between the main electrode and the eyelid.

20. A method according to claim 18, further comprising disposing an insert between the eyelid and the eyeball, the insert comprising the active substance and being disposed between the main electrode and the eyeball.

21. A method according to claim 18, wherein the electrical current is a direct current (DC) having an amplitude between about 0.5 mA and about 10 mA.

22. A method according to claim 18, further comprising impregnating an absorbent foam layer within the main electrode with the active substance.

23. A method according to claim 18, wherein the active substance penetrates through the eyelid via iontophoresis.

24. A method according to claim 18, wherein the active substance penetrates through the eyeball via iontophoresis.