TREATMENT OF RENAL HYPERTENSION OR CAROTID SINUS SYNDROME WITH ADVENTITIAL PHARMACEUTICAL SYMPATHETIC DENERVATION OR NEUROMODULATION
First Claim
1. A method for treating hypertension, said method comprising the delivery of an amount of a neuromodulating agent to the nerves surrounding a blood vessel, wherein the amount is effective to lower systemic blood pressure by a therapeutically beneficial amount.
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Abstract
Sympathetic nerves run through the adventitia surrounding renal arteries and are critical in the modulation of systemic hypertension. Hyperactivity of these nerves can cause renal hypertension, a disease prevalent in 30-40% of the adult population. Hypertension can be treated with neuromodulating agents (such as angiotensin converting enzyme inhibitors, angiotensin II inhibitors, or aldosterone receptor blockers), but requires adherence to strict medication regimens and often does not reach target blood pressure threshold to reduce risk of major cardiovascular events. A minimally invasive solution is presented here to reduce the activity of the sympathetic nerves surrounding the renal artery by locally delivering neurotoxic or nerve-blocking agents into the adventitia. Extended elution of these agents may also be accomplished in order to tailor the therapy to the patient.
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Citations
18 Claims
- 1. A method for treating hypertension, said method comprising the delivery of an amount of a neuromodulating agent to the nerves surrounding a blood vessel, wherein the amount is effective to lower systemic blood pressure by a therapeutically beneficial amount.
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14. A method for treating hypertension, said method comprising the delivery of a therapeutically effective amount of heated fluid into the perivascular tissue surrounding the renal artery.
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15. A device for the treatment of hypertension comprising:
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an inflatable balloon that, when inflated, positions a needle within a vessel wall for the delivery of fluids outside and around the vessel wall; an electrically resistive heating element positioned along the pathway of the injected fluid, wherein the heating element is connected to a proximal energy source and control circuitry; and a thermosensor positioned distal to the resistive heating element, wherein the thermosensor is connected to a proximal energy source and is capable of feeding back a signal to the control circuitry for the purpose of controlling the temperature of the resistive heating element.
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16. A system for treating hypertension, said system comprising:
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a catheter adapted to be introduced into a patient'"'"'s vasculature; a needle adapted to be deployed from the catheter through a blood vessel wall into the adventitia surrounding the blood vessel; and a source of a neuromodulating agent which can be delivered through the needle into the adventitia to lower the systemic blood pressure of the patient by a therapeutically beneficial amount. - View Dependent Claims (17, 18)
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Specification