METHODS FOR IN VIVO EVALUATION OF PULMONARY PHYSIOLOGY AND/OR FUNCTION USING NMR SIGNALS OF POLARIZED 129XE
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Abstract
In certain embodiments, methods of the present invention obtain dynamic data sets of an NMR spectroscopy signal of polarized 129Xe in a selected structure, environment, or system. The signal data can be used to evaluate: (a) the physiology of a membrane or tissue; (b) the operational condition or function of a body system or portion thereof (when at rest or under stimulation); and/or (c) the efficacy of a therapeutic treatment used to treat a diagnosed disorder, disease, or condition. Thus, the present invention provides methods for screening and/or diagnosing a respiratory, cardiopulmonary disorder or disease such as chronic heart failure, and/or methods for monitoring the efficacy of therapeutics administered to subject to treat the disorder or disease.
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Citations
101 Claims
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1-67. -67. (canceled)
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68. An in vivo method for evaluating respiratory, pulmonary and/or cardiopulmonary physiology and/or function, comprising:
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(a) delivering polarized 129Xe in vivo to a subject such that the polarized 129Xe moves serially from an alveolar gas compartment through a tissue compartment with thickness LT, a capillary compartment with thickness LC comprising plasma and red blood cells, and is then taken away in the blood stream; (b) obtaining NMR spectroscopic signals of the polarized 129Xe in the subject over time at selected chemical shift frequencies to generate at least one dynamic data set of the NMR spectroscopic signal strength over time after successively destroying the polarization of the 129Xe repetitively at predetermined delays in the compartments; and (c) calculating a plurality of selected parameters associated with lung function and/or physiology according to a predetermined mathematical diffusion model of alveolar gas exchange using the NMR-derived dynamic data set. - View Dependent Claims (69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 92, 93, 94, 95, 96, 97, 98, 99, 100)
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- 89. (canceled)
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101-124. -124. (canceled)
Specification