Porcine Reproductive and Respiratory Syndrome Vaccine Based on Isolate JA-142
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Abstract
Substantially avirulent forms of atypical porcine reproductive and respiratory syndrome (PRRS) virus and corresponding vaccines are provided which result from cell culture passaging of virulent forms of PRRS. The resultant avirulent atypical PRRS virus is useful as a vaccine in that PRRS specific antibody response is elicited by inoculation of host animals, thereby conferring effective immunity against both previously known strains of PRRS virus and newly isolated atypical PRRS virus strains. The preferred passaging technique ensures that the virus remains in a logarithmic growth phase substantially throughout the process, which minimizes the time required to achieve attenuation. The present invention also provides diagnostic testing methods which can differentiate between animals infected with field strains and attenuated strains of PRRSV.
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Citations
31 Claims
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1-3. -3. (canceled)
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4. A method of reducing reproductive or respiratory failure in swine comprising the steps of:
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providing a vaccine, said vaccine comprising at least one attenuated strain of PRRSV; administering said vaccine to said swine. - View Dependent Claims (5, 6, 7, 8, 9, 10, 11)
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12-16. -16. (canceled)
- 17. An isolated DNA sequence having at least about 80% sequence identity with a sequence selected from the group consisting of SEQ ID No. 1 or SEQ ID No. 2.
Specification