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GALENIC APPLICATIONS OF SELF-EMULSIFYING MIXTURES OF LIPIDIC EXCIPIENTS

  • US 20110104268A1
  • Filed: 08/27/2010
  • Published: 05/05/2011
  • Est. Priority Date: 07/27/2004
  • Status: Abandoned Application
First Claim
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1. A method of enhancing the absorption of an active principle by a mechanism involving inhibition of efflux pumps, comprising orally administering a pharmaceutical composition, wherein the pharmaceutical composition comprises:

  • a self-emulsifying mixture, said self-emulsifying mixture comprisingone or more lipid excipients in an amount of 40 to 85%, the one or more lipid excipients being selected from the group consisting of glyceryl linoleate, glyceryl mono-oleate, glyceryl oleate/linoleate, glyceryl laurate, polyglyceryl-3 oleate, soybean oil, capric/caprylic/lauric acid triglycerides, and oleic acid,one or more surfactants in an amount of 15 to 50%, andoptionally one or more cosurfactants; and

    one or more active principles.

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