MEDICAL COMPOSITION AND MEDICAL KIT

• US 20110104292A1
• Filed: 06/26/2009
• Published: 05/05/2011
• Est. Priority Date: 06/27/2008
• Status: Active Grant

• Current Assignee: National Cerebral And Cardiovascular Center, Osaka City University
• Original Assignee: Japan Health Sciences Foundation, Osaka City University
• Inventors: Furuzono, Tsutomu, Fukumoto, Shinya, Nishizawa, Yoshiki, Okada, Masahiro, Koyama, Hidenori
• Granted Patent: US 9,642,938 B2
• Time in Patent Office: Days
• US Class Current: 424/490
• CPC Class Codes: A61K 31/74 Synthetic polymeric materials
• CPC Class Codes: A61K 9/16 Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction A61K9/20 takes precedence if the final form is a tablet; microspheres with drug-free outer coating, microcapsules A61K9/50; mixture of different granules, microcapsules, (coated) microparticles A61K9/5084; nanoparticles A61K9/51
• CPC Class Codes: A61L 2300/414 Growth factors
• CPC Class Codes: A61L 2300/426 Immunomodulating agents, i.e. cytokines, interleukins, interferons
• CPC Class Codes: A61L 27/32 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61L 27/3804 characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body

Abstract

In order to provide (i) a medical composition that has a strong angiogenic effect, has low invasiveness to a body of a patient, and is easy to administer to a living subject and (ii) a medical kit using a medical composition, the medical composition includes: a carrier in a particle form, the carrier having (a) a support made from a bioabsorbable polymer and (b) a surface layer made from hydroxyapatite and provided on the support; and cells provided on a surface of the carrier.

Claims

1. A medical composition, comprising:

a carrier in a particle form, the carrier having (i) a support made from a bioabsorbable polymer and (ii) a surface layer made from hydroxyapatite and provided on the support; and

cells provided on a surface of the carrier.

2. The medical composition according to claim 1, wherein the carrier falls within a range of 10 μ

m to 200 μ

m in particle diameter.

3. The medical composition according to claim 1, wherein the carrier has a porous structure.

4. The medical composition according to claim 1, wherein the bioabsorbable polymer is at least one selected from the group consisting of:

polylactic acid, polyglycolic acid, polyethylene glycol, propylene glycol, polyhydroxybutylate, polycarbonate, polyamide, cellulose, chitin, chitosan, starch, polyglutamic acid, polydioxanone, cyanoacrylate polymers, polycaprolactone, synthetic polypeptides, hyaluronic acid, polymalic acid, poly butylene succinate, and copolymers of any combination thereof.

5. The medical composition according to claim 1, wherein the cells are at least one kind selected from the group consisting of:

myelomonocytic cells, peripheral-blood mononuclear cells, multipotent stem cells, hematopoietic stem cells, vascular endothelium precursor cells, iPS cells, ES cells, platelet, and mesenchymal stem cells.

6. The medical composition according to claim 1, further comprising angiogenesis cytokine provided on the surface of the carrier.

7. The medical composition according to claim 6, wherein the angiogenesis cytokine is at least one selected from the group consisting of:

aFGF, bFGF, VEGF, HGF, PDGF, PIGF, TNF, EGF, angiopoietin, IL, HAPO, Shh, TGF-β

, G-CSF, M-CSF, SCF, EPO, TPO, and Flt.

8. A medical kit, comprising:

a medical composition recited in claim 1; and

an injector for administering the medical composition to a living subject.

9. A method of producing a medial composition, comprising mixing (i) a carrier in a particle form and (ii) cells, the carrier having (a) a support made from a bioabsorbable polymer and (b) a surface layer made from hydroxyapatite and provided on the support.

10. The method according to claim 9, wherein, in the step of mixing, a number of said cells to be added is less than or equal to 1×

10¹⁰per particle of said carrier.