NUCLEIC ACID LIGANDS AGAINST INFECTIOUS PRIONS
First Claim
1. An isolated nucleic acid ligand that binds to an infectious prion.
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Accused Products
Abstract
The invention generally relates to nucleic acid ligands that specifically bind to infectious prions, and methods of diagnosing a transmissible spongiform encephalopathy disease in a subject. In certain embodiments, the invention provides an isolated nucleic acid ligand that binds to an infectious prion. In other embodiments, the invention provides a method for diagnosing a transmissible spongiform encephalopathy disease in a subject including obtaining a tissue or body fluid sample from a subject, contacting the tissue or body fluid with a nucleic acid ligand that binds to an infectious prion, thereby detecting the infectious prion in the sample, and diagnosing the transmissible spongiform encephalopathy disease based on results of the contacting step.
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Citations
36 Claims
- 1. An isolated nucleic acid ligand that binds to an infectious prion.
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9. A method for diagnosing a transmissible spongiform encephalopathy disease in a subject comprising:
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providing a tissue or body fluid sample from a subject; contacting the tissue or body fluid with a nucleic acid ligand that binds to an infectious prion, thereby detecting the infectious prion in the sample; and diagnosing the transmissible spongiform encephalopathy disease based on results of the contacting step. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. An isolated nucleotide sequence comprising SEQ ID NO:
- 1 or a nucleotide sequence substantially identical thereto.
- View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27)
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28. An isolated nucleotide sequence comprising SEQ ID NO:
- 2 or a nucleotide sequence substantially identical thereto.
- View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36)
Specification