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MICROFABRICATION METHODS FOR THE OPTIMAL PATTERNING OF SUBSTRATES

  • US 20110105366A1
  • Filed: 06/18/2008
  • Published: 05/05/2011
  • Est. Priority Date: 06/18/2007
  • Status: Abandoned Application
First Claim
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1. A method of fabricating a microarray, comprising:

  • (a) providing a substrate having at least two layers of different chemical reactivity, wherein a well in an outer layer exposes an inner layer;

    (b) contacting said substrate with a first reagent specifically reactive with said outer layer to produce a first modified layer;

    (c) contacting said substrate with a second reagent specifically reactive with said inner layer of said substrate to produce a modified inner layer, wherein said modified inner layer has a higher affinity for a biopolymer than said modified outer layer, and(d) depositing said biopolymer onto said modified inner layer within said well, wherein said higher affinity of said modified inner layer facilitates localization of said biopolymer onto said well.

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