INDOLE BASED RECEPTOR CRTH2 ANTAGONISTS

• US 20110105509A1
• Filed: 11/03/2010
• Published: 05/05/2011
• Est. Priority Date: 11/04/2009
• Status: Abandoned Application

• Current Assignee: Wyeth LLC (Pfizer Inc.)
• Original Assignee: Wyeth LLC (Pfizer Inc.)
• Inventors: Saiah, Eddine, Lowe, Michael Dennis, Thomason, Jennifer Romanic, Moretto, Alessandro Fabio, Janz, Kristin Marie, Williams, Cara Margaret May, Huang, Adrian, Follows, Bruce Christopher, Mansour, Tarek Suhayl, Kaila, Neelu
• Application Number:
  US12/938,479
• Publication Number:
  US 20110105509A1
• Time in Patent Office: Days
• US Class Current: 514/248
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 37/06 Immunosuppressants, e.g. drugs for graft rejection
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: C07D 401/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 401/06 linked by a carbon chain containing only aliphatic carbon atoms
• CPC Class Codes: C07D 401/14 containing three or more hetero rings
• CPC Class Codes: C07D 403/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 403/06 linked by a carbon chain containing only aliphatic carbon atoms
• CPC Class Codes: C07D 403/14 containing three or more hetero rings
• CPC Class Codes: C07D 417/14 containing three or more hetero rings

Abstract

Disclosed are compounds of Formula (I):

• • which are useful as antagonists of the CRTH2 receptors. Pharmaceutical compositions containing compounds of Formula (I) and the use of compounds of Formula (I) to treat diseases or disorders that are responsive to inhibition of the binding of endogenous ligands to the CRTH2 receptor are also disclosed. Methods for preparing and using these compounds are further described.

Claims

1. A compound of Formula (I):

2. The compound of claim 1, wherein R₁ is halogen.

3. The compound of claim 1, wherein R₁ is alkyl.

4. The compound of claim 1, wherein R₁ is SO₂Me.

5. The compound of claim 1, wherein R₂ is halogen.

6. The compound of claim 1, wherein R₂ is alkyl.

7. The compound of claim 1, wherein R₂ is SO₂Me.

8. The compound of claim 1, wherein R₃ is alkyl optionally substituted with alkyl, aryl, heteroaryl, cycloalkyl, alkoxy, halogen, hydroxy, amino, mono- or di-alkylamino, nitro, haloalkyl, haloalkoxy, carboxamide, sulfonamide or SO₂Me.

9. The compound of claim 1, wherein R₃ is aryl optionally substituted with alkyl, aryl, heteroaryl, cycloalkyl, alkoxy, halogen, hydroxy, amino, mono- or di-alkylamino, nitro, haloalkyl, haloalkoxy, carboxamide, sulfonamide or SO₂Me.

10. The compound of claim 1, wherein R₃ is heteroaryl optionally substituted with alkyl, aryl, heteroaryl, cycloalkyl, alkoxy, halogen, hydroxy, amino, mono- or di-alkylamino, nitro, haloalkyl, haloalkoxy, carboxamide, sulfonamide or SO₂Me.

11. The compound of claim 1, wherein R₃ is cycloalkyl optionally substituted with alkyl, aryl, heteroaryl, cycloalkyl, alkoxy, halogen, hydroxy, amino, mono- or di-alkylamino, nitro, haloalkyl, haloalkoxy, carboxamide, sulfonamide or SO₂Me.

12. The compound of claim 1, wherein R₄ is alkyl.

13. The compound of claim 1, wherein R₅ is CH₂COOH.

14. The compound of claim 1, wherein R₅ is CH₂CONHSO₂Me.

15. The compound of claim 1, wherein X is CH.

16. The compound of claim 1, wherein X is N.

17. The compound of claim 1, wherein n is 0.

18. The compound of claim 1, wherein n is 1.

19. The compound of claim 1, wherein the compound is selected from the group consisting of:

2-(5-Chloro-3-(3-(4-chlorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-(3-(4-chloro-3-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-(3-(3-fluoro-4-(trifluoromethyl)benzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(3-(4-Chlorobenzyl)-4-oxo-3,4-dihydropthalazin-1-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(3-(4-Chloro-3-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-3-(3-(3-fluoro-4-(trifluoromethyl)benzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(3-(2,4-dichlorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-(1-(4-chloro-3-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-(1-(4-chlorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-Benzyl-6-oxo-1,6-dihydropyridazin-3-yl)-5-chloro-7-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(3-Benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)-5-chloro-7-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-(4-Chloro-3-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-(4-Chlorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(3-Benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)-7-chloro-2-methyl-5-(methylsulfonyl)-1H-indol-1-yl)acetic acid;

2-(3-(3-Benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)-7-fluoro-2-methyl-5-(methylsulfonyl)-1H-indol-1-yl)acetic acid;

2-(3-(3-Benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)-5-methoxy-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-Benzyl-6-oxo-1,6-dihydropyridazin-3-yl)-7-fluoro-2-methyl-5-(methylsulfonyl)-1H-indol-1-yl)acetic acid;

2-(3-(1-Benzyl-6-oxo-1,6-dihydropyridazin-3-yl)-5-methoxy-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(3-Isopropyl-4-oxo-3,4-dihydrophthalazin-1-yl)-5-methoxy-2-methyl-1H-indol-1-yl)-acetic acid;

2-(3-((1-(2,4-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-((1-(2,4-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-((1-Isopropyl-6-oxo-1,6-dihydropyridin-3-yl)methyl-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-((6-oxo-1-(2,4,5-trifluorobenzyl)-1,6-dihydropyridin-3-yl)methyl)-1H-indol-1-yl)acetic acid;

2-(2-Methyl-3-((6-oxo-1-(2,4,5-trifluorobenzyl)-1,6-dihydropyridin-3-yl)methyl-1H-indol-1-yl)acetic acid;

2-(3-((1-(2,5-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-((1-(2,5-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-fluoro-3-((1-isopropyl-6-oxo-1,6-dihydropyridin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-((1-(2,3-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-(2,3-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-((1-(3,4-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-((1-(2-Fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-2-methyl-1H-indol-1-yl)-acetic acid;

2-(5-Fluoro-3-((1-(2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-((1-(3,4-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-((1-(3-Fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-2-methyl-1H-indol-1-yl)-acetic acid;

2-(3-((1-(3,5-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-((1-(3,5-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-((1-(2,6-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-((1-(2,6-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-3-((1-(3-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-((1-(4-Fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-2-methyl-1H-indol-1-yl)-acetic acid;

2-(5-Fluoro-3-((1-(4-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-((1-(2,4-difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-((1-(2,3-difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-2-methyl-3-((6-oxo-1-(2,4,5-trifluorobenzyl)-1,6-dihydropyridin-3-yl)methyl)-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-((1-(3-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-((6-oxo-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridin-3-yl)methyl-1H-indol-1-yl)acetic acid;

2-(3-(3-Benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetamide;

2-(3-(3-Benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)-N,N-dimethylacetamide;

2-Benzyl-4-(2-methyl-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-1H-indol-3-yl)phthalazin-1(2H)-one;

2-(3-(3-Benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)-N-(methyl-sulfonyl)acetamide;

4-(1-((2H-Tetrazol-5-yl)methyl)-2-methyl-1H-indol-3-yl)-2-benzylphthalazin-1(2H)-one;

2-Benzyl-4-(1-(2-hydroxyethyl)-2-methyl-1H-indol-3-yl)phthalazin-1(2H)-one;

2-(5-Chloro-2-methyl-3-((6-oxo-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridin-3-yl)methyl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-((6-oxo-1-(4,4,4-trifluorobutyl)-1,6-dihydropyridin-3-yl)methyl)-1H-indol-1-yl)acetic acid;

2-(4-Acetamido-3-((1-(2,4-difluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-((1-(2,4-Difluorobenzyl)-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-((6-oxo-1-(2,2,2-trifluoroethyl)-1,4,5,6-tetrahydropyridazin-3-yl)-methyl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-((6-oxo-1-(4,4,4-trifluorobutyl)-1,4,5,6-tetrahydropyridazin-3-yl)-methyl)-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-(3-(2,5-difluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-2-methyl-3-(4-oxo-3-(2,4,5-trifluorobenzyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-(3-(2,4-difluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(3-(2,5-Difluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(4-oxo-3-(2,4,5-trifluorobenzyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(3-(3-(2,4-Difluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(3-(4-(methylsulfonyl)benzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(5-Chloro-2-methyl-3-(1-(4-(methylsulfonyl)benzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-(1-(2,5-difluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-(1-(2,4-difluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-2-methyl-3-(6-oxo-1-(2,4,5-trifluorobenzyl)-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(6-oxo-1-(2,4,5-trifluorobenzyl)-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)acetic acid;

2-(3-(1-(2,4-Difluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-(2,5-Difluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(1-(4-(methylsulfonyl)benzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)acetic acid;

2-(3-((1-(2-Fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-((1-(3-Fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1- yl)acetic acid;

2-(3-((1-(4-Fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-((1-Benzyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-((1-Benzyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-((1-(2,3-Difluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-((1-Benzyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-5-chloro-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-2-methyl-3-((6-oxo-1-(4-(trifluoromethyl)benzyl)-1,6-dihydropyridazin-3-yl)-methyl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-((6-oxo-1-(4-(trifluoromethyl)benzyl)-1,6-dihydropyridazin-3-yl)-methyl)-1H-indol-1-yl)acetic acid;

2-(3-((1-(2,4-Difluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-((3-Benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)methyl)-5-chloro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-((2-Benzyl-1-oxo-1,2-dihydroisoquinolin-4-yl)methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-((2-Benzyl-1-oxo-1,2-dihydroisoquinolin-4-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-((2-Benzyl-1-oxo-1,2-dihydroisoquinolin-4-yl)methyl)-5-chloro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(2-Benzyl-1-oxo-1,2,5,6,7,8-hexahydroisoquinolin-4-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(1-oxo-2-(4,4,4-trifluorobutyl)-1,2,5,6,7,8-hexahydroisoquinolin-4-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(1-oxo-2-(2,2,2-trifluoroethyl)-1,2,5,6,7,8-hexahydroisoquinolin-4-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-3-(2-isopropyl-1-oxo-1,2,5,6,7,8-hexahydroisoquinolin-4-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-3-(2-(2-hydroxy-2-methylpropyl)-1-oxo-1,2,5,6,7,8-hexahydroisoquinolin-4-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(1-oxo-2-phenethyl-1,2,5,6,7,8-hexahydroisoquinolin-4-yl)-1H-indol-1-yl)acetic acid;

2-(3-(2-(2,4-Difluorobenzyl)-1-oxo-1,2,5,6,7,8-hexahydroisoquinolin-4-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(1-oxo-2-(pyridin-2-ylmethyl)-1,2-dihydroisoquinolin-4-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(1-oxo-2-(4,4,4-trifluoro-3-(trifluoromethyl)butyl)-1,2-dihydro-isoquinolin-4-yl)-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-(3-(2,3-difluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-(3-(2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-(3-((5-fluorobenzo[d]thiazol-2-yl)methyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-2-methyl-3-(4-oxo-3-((5-(trifluoromethyl)benzo[d]thiazol-2-yl)methyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-(3-(2,6-difluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-2-methyl-3-(4-oxo-3-(4-(trifluoromethoxy)benzyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(5-Chloro-2-methyl-3-(4-oxo-3-(quinolin-2-ylmethyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(5-Chloro-2-methyl-3-(3-((2-methylquinolin-4-yl)methyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(5-Chloro-2-methyl-3-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)-acetic acid;

2-(5-Chloro-3-(3-ethyl-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-(3-isopropyl-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-(3-(cyclopropylmethyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-2-methyl-3-(4-oxo-3-(2,2,2-trifluoroethyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(3-(3-(Benzo[d]thiazol-2-ylmethyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-3-(3-(4-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(3-(2,3-Difluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-3-(3-(2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-3-(3-((5-fluorobenzo[d]thiazol-2-yl)methyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(4-oxo-3-((5-(trifluoromethyl)benzo[d]thiazol-2-yl)methyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(3-(3-(2,6-Difluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(4-oxo-3-(4-(trifluoromethoxy)benzyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(4-oxo-3-(quinolin-2-ylmethyl)-3,4-dihydrophthalazin-1-yl)-1H- indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(3-((2-methylquinolin-4-yl)methyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(3-(3-Ethyl-4-oxo-3,4-dihydrophthalazin-1-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(3-(Cyclopropylmethyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(3-Cyclopropyl-4-oxo-3,4-dihydrophthalazin-1-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(4-oxo-3-(2,2,2-trifluoroethyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(4-oxo-3-(4,4,4-trifluorobutyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(3-neopentyl-4-oxo-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)-acetic acid;

2-(5-Fluoro-2-methyl-3-(4-oxo-3-(3,3,3-trifluoropropyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(3-(3-(2-Ethyl-2-hydroxybutyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-3-(3-(2-hydroxy-2-methylpropyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(3-(3-methylbut-2-enyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(4-oxo-3-(3,3,3-trifluoro-2-hydroxy-2-(trifluoromethyl)propyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-3-(3-(3-hydroxy-3-methylbutyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(4-oxo-3-(2-oxobutyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)-acetic acid;

2-(5-Fluoro-2-methyl-3-(4-oxo-3-(pyridin-4-ylmethyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(4-oxo-3-(pyridin-3-ylmethyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(4-oxo-3-(pyridin-2-ylmethyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(4-oxo-3-(4,4,4-trifluoro-3-(trifluoromethyl)butyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-3-(3-((3-fluoropyridin-4-yl)methyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-(1-(4-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-(1-(2-(4-chlorophenoxy)ethyl)-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-(Benzo[d]thiazol-2-ylmethyl)-6-oxo-1,6-dihydropyridazin-3-yl)-5-chloro-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-(1-(4-fluoro-2-(trifluoromethyl)benzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-(1-(3-fluoro-2-(trifluoromethyl)benzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-2-methyl-3-(6-oxo-1-(quinolin-2-ylmethyl)-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)acetic acid;

2-(5-chloro-2-methyl-3-(1-((2-methylquinolin-4-yl)methyl)-6-oxo-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)acetic acid;

2-(5-Chloro-2-methyl-3-(1-(4-methylbenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-(1-(4-isopropylbenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-chloro-3-(1-(4-methoxybenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-2-methyl-3-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)-acetic acid;

2-(5-Chloro-3-(1-ethyl-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-3-(1-(4-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-(2-(4-Chlorophenoxy)ethyl)-6-oxo-1,6-dihydropyridazin-3-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-(Benzo[d]thiazol-2-ylmethyl)-6-oxo-1,6-dihydropyridazin-3-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-3-(1-(3-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-3-(1-(4-fluoro-2-(trifluoromethyl)benzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-3-(1-(3-fluoro-2-(trifluoromethyl)benzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-fluoro-2-methyl-3-(6-oxo-1-(quinolin-2-ylmethyl)-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(1-((2-methylquinolin-4-yl)methyl)-6-oxo-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)acetic acid;

2-(3-(1-Ethyl-6-oxo-1,6-dihydropyridazin-3-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-(Cyclopropylmethyl)-6-oxo-1,6-dihydropyridazin-3-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(6-oxo-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(6-oxo-1-(4,4,4-trifluorobutyl)-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(6-oxo-1-(3,3,3-trifluoropropyl)-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(1-neopentyl-6-oxo-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)acetic acid;

2-(3-(3-(4-Fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(3-(Benzo[d]thiazol-2-ylmethyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(2-Methyl-3-(3-(4-(methylsulfonyl)benzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(2-Methyl-3-(4-oxo-3-(quinolin-2-ylmethyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-acetic acid;

2-(2-methyl-3-(4-oxo-3-(4-(trifluoromethoxy)benzyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)-1-yl)acetic acid;

2-(2-Methyl-3-(4-oxo-3-(4-(trifluoromethyl)benzyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(3-(3-(2,6-Difluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(2-Methyl-3-(3-(4-methylbenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)-acetic acid;

2-(2-Methyl-3-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(3-(3-Ethyl-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(3-(Cyclopropylmethyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(2-Methyl-3-(4-oxo-3-(2,2,2-trifluoroethyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)-acetic acid;

2-(3-(3-cyclopropyl-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(3-Cyclopentyl-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-Benzyl-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-Isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-Ethyl-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(2-Methyl-3-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)acetic acid;

2-(3-(1-(Cyclopropylmethyl)-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)-acetic acid;

2-(2-Methyl-3-(6-oxo-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)-acetic acid;

Methyl 2-(3-(1-(2,4-difluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)acetate;

2-(2-Methyl-3-(6-oxo-1-(2,4,5-trifluorobenzyl)-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)-acetic acid;

2-(3-(1-(2,3-Difluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)-acetic acid;

2-(3-(1-(4-Fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-(2-Fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-Benzyl-6-oxo-1,6-dihydropyridazin-3-yl)-2,5-dimethyl-1H-indol-1-yl)acetic acid;

2-(3-(3-Benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)-2,5-dimethyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-((6-oxo-1-(2,4,5-trifluorobenzyl)-1,6-dihydropyridazin-3-yl)-methyl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-((6-oxo-1-(pyridin-4-ylmethyl)-1,6-dihydropyridazin-3-yl)methyl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-((6-oxo-1-(pyridin-3-ylmethyl)-1,6-dihydropyridazin-3-yl)methyl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-((6-oxo-1-(pyridin-2-ylmethyl)-1,6-dihydropyridazin-3-yl)methyl)-1H-indol-1-yl)acetic acid;

(5-Fluoro-3-{[1-(2-hydroxy-2-methylpropyl)-6-oxo-1,6-dihydropyridazin-3-yl]methyl}-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-2-methyl-3-(4-oxo-3-(4-(trifluoromethyl)benzyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(5-Chloro-2-methyl-3-(4-oxo-3-(2-(trifluoromethyl)benzyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(5-Chloro-2-methyl-3-(4-oxo-3-(3-(trifluoromethyl)benzyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

[5-fluoro-2-methyl-3-({6-oxo-1-[3,3,3-trifluoro-2-hydroxy-2-(trifluoromethyl)propyl]-1,6-dihydro-pyridazin-3-yl}methyl)-1H-indol-1-yl]acetic acid;

2-(5-Fluoro-2-methyl-3-(4-oxo-3-(2-(trifluoromethyl)benzyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(4-oxo-3-(3-(trifluoromethyl)benzyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(4-oxo-3-(4-(trifluoromethyl)benzyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(4-oxo-3-phenyl-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(4-oxo-3-(4-(trifluoromethyl)phenyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(4-oxo-3-(3-(trifluoromethyl)phenyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(3-(3-((5-Chlorobenzo[d]thiazol-2-yl)methyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-(3-((5-chlorobenzo[d]thiazol-2-yl)methyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(3-(2-(4-Chlorophenoxy)ethyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-2-methyl-3-(6-oxo-1-(2-(trifluoromethyl)benzyl)-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)acetic acid;

2-(5-Chloro-2-methyl-3-(6-oxo-1-(3-(trifluoromethyl)benzyl)-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)acetic acid;

2-(5-Chloro-2-methyl-3-(6-oxo-1-(4-(trifluoromethyl)benzyl)-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)acetic acid;

2-(3-(1-Benzyl-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-5-(methylsulfonyl)-1H-indol-1-yl)acetic acid;

2-(3-(3-Benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-5-(methylsulfonyl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(6-oxo-1-(2-(trifluoromethyl)benzyl)-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(6-oxo-1-(3-(trifluoromethyl)benzyl)-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(6-oxo-1-(3-(trifluoromethyl)benzyl)-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)acetic acid;

2-(3-(1-Benzyl-6-oxo-1,6-dihydropyridazin-3-yl)-5-bromo-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(3-(2-methyl-2-phenoxypropyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(5-Chloro-2-methyl-3-(4-oxo-3-(2-phenoxyethyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(4-oxo-3-(2-phenoxyethyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(2-Methyl-3-(4-oxo-3-(2-phenoxyethyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(3-(3-(4-Fluorophenethyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)-acetic acid;

2-(2-Methyl-3-(4-oxo-3-phenethyl-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(4-oxo-3-phenethyl-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)-acetic acid;

2-(5-Fluoro-3-(3-(4-fluorophenethyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(2-Methyl-3-(6-oxo-1-phenethyl-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)acetic acid;

2-(3-(1-(4-Fluorophenethyl)-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)-acetic acid;

2-(5-Fluoro-2-methyl-3-(1-(2-methyl-2-phenoxypropyl)-6-oxo-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)acetic acid;

2-(3-(1-Benzyl-6-oxo-1,6-dihydropyridazin-3-yl)-7-chloro-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(7-Chloro-5-fluoro-3-(1-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-Benzyl-6-oxo-1,6-dihydropyridazin-3-yl)-5,7-difluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-Benzyl-6-oxo-1,6-dihydropyridazin-3-yl)-5,7-dichloro-2-methyl-1H-indol-1-yl)-acetic acid;

2-(5,7-Dichloro-3-(1-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)-acetic acid;

2-(3-(1-Benzyl-6-oxo-1,6-dihydropyridazin-3-yl)-5-fluoro-2-methyl-7-(methylsulfonyl)-1H-indol-1-yl)acetic acid;

2-(3-(3-Benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)-5-fluoro-2-methyl-7-(methylsulfonyl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-3-((1-(4-(2-hydroxypropan-2-yl)benzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-methyl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-3-((1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-3-((1-(3-(2-hydroxypropan-2-yl)benzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-methyl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-3-((1-((3-fluoropyridin-4-yl)methyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-((1-(2,4-Difluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-5,7-difluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(3-Benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)-7-chloro-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(3-Benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)-5,7-difluoro-2-methyl-1H-indol-1-yl)-acetic acid;

2-(3-(3-Benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)-5,7-dichloro-2-methyl-1H-indol-1-yl)-acetic acid;

2-(3-(1-Benzyl-6-oxo-1,6-dihydropyridazin-3-yl)-7-bromo-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(2-Benzyl-1-oxo-1,2-dihydroisoquinolin-4-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(2-Benzyl-1-oxo-1,2-dihydroisoquinolin-4-yl)-5-fluoro-2-methyl-1H-indol-1-yl)-acetic acid;

2-(5-Fluoro-3-(2-isopropyl-1-oxo-1,2-dihydroisoquinolin-4-yl)-2-methyl-1H-indol-1-yl)-acetic acid;

2-(5-Fluoro-2-methyl-3-(1-oxo-2-(2,2,2-trifluoroethyl)-1,2-dihydroisoquinolin-4-yl)-1H-indol-1-yl)acetic acid;

2-(2-Methyl-3-(1-oxo-2-(2,2,2-trifluoroethyl)-1,2-dihydroisoquinolin-4-yl)-1H-indol-1-yl)-acetic acid;

2-(3-(2-Isopropyl-1-oxo-1,2-dihydroisoquinolin-4-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(2-(2,2-Difluoro-2-methoxyethyl)-1-oxo-1,2-dihydroisoquinolin-4-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-3-(2-(2-hydroxy-2-methylpropyl)-1-oxo-1,2-dihydroisoquinolin-4-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(1-oxo-2-(3,3,3-trifluoro-2-hydroxy-2-(trifluoromethyl)propyl)-1,2-dihydroisoquinolin-4-yl)-1H-indol-1-yl)acetic acid;

(5-Fluoro-2-methyl-3-(1-oxo-2-(4,4,4-trifluorobutyl)-1,2-dihydroisoquinolin-4-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(2-neopentyl-1-oxo-1,2-dihydroisoquinolin-4-yl)-1H-indol-1-yl)acetic acid;

2-(3-(3-((4H-1,2,4-Triazol-3-yl)methyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(3-(2-Amino-2-oxoethyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-5-chloro-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-2-methyl-3-(3-((5-methyl-4H-1,2,4-triazol-3-yl)methyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-(3-(3-((4H-1,2,4-Triazol-3-yl)methyl)-4-oxo-3,4-dihydrophthalazin-1-yl)-5-chloro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-((4H-1,2,4-Triazol-3-yl)methyl)-6-oxo-1,6-dihydropyridazin-3-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(1-((5-methyl-4H-1,2,4-triazol-3-yl)methyl)-6-oxo-1,6-dihydropyridazin-3-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(4-oxo-3-((1-phenyl-1H-1,2,4-triazol-5-yl)methyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)acetic acid;

2-Benzyl-6-(5-fluoro-1-(4-methoxybenzoyl)-2-methyl-1H-indol-3-yl)pyridazin-3(2H)-one;

2-Benzyl-6-(5-fluoro-2-methyl-1-nicotinoyl-1H-indol-3-yl)pyridazin-3(2H)-one;

6-(1-Benzyl-5-fluoro-2-methyl-1H-indol-3-yl)-2-benzylpyridazin-3(2H)-one;

2-(3-(1-Benzyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-Benzyl-6-oxo-1,6-dihydropyridin-3-yl)-5-chloro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-Benzyl-6-oxo-1,6-dihydropyridin-3-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-3-(1-(2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-2-methyl-1H-indol-1-yl)-acetic acid;

2-(5-Fluoro-3-(1-(4-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-2-methyl-1H-indol-1-yl)-acetic acid;

2-(3-(1-(2,6-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-(2,3-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-(2,4-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(6-oxo-1-(2,4,5-trifluorobenzyl)-1,6-dihydropyridin-3-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-3-(2-(3-hydroxy-3-methylbutyl)-1-oxo-1,2-dihydroisoquinolin-4-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-(1-(2,4-difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-(2,4-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-Isopropyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-3-(1-isopropyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-(1-isopropyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methyl-1H-indol-1yl)acetic acid;

2-(2-Methyl-3-(6-oxo-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridin-3-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(6-oxo-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridin-3-yl)-1H-indol-1-yl)acetic acid;

2-(5-Chloro-2-methyl-3-(6-oxo-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridin-3-yl)-1H-indol-1-yl)acetic acid;

2-(3-(1-(2-Fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-(4-Fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-(2,3-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-(2,6-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(2-Methyl-3-(6-oxo-1-(2,4,5-trifluorobenzyl)-1,6-dihydropyridin-3-yl)-1H-indol-1-yl)-acetic acid;

2-(3-(1-Isobutyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(3-(1-Cyclopentyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-(1-(4-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-2-methyl-1H-indol-1-yl)-acetic acid;

2-(5-Chloro-3-(1-(2-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-2-methyl-1H-indol-1-yl)-acetic acid;

2-(5-Chloro-3-(1-(2,6-difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-(1-(2,3-difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-2-methyl-3-(6-oxo-1-(2,4,5-trifluorobenzyl)-1,6-dihydropyridin-3-yl)-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-(1-(3,5-difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Chloro-3-(1-(3-fluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-2-methyl-1H-indol-1-yl)-acetic acid;

2-(2-Methyl-3-(6-oxo-1-(4,4,4-trifluorobutyl)-1,6-dihydropyridin-3-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(6-oxo-1-(4,4,4-trifluorobutyl)-1,6-dihydropyridin-3-yl)-1H-indol-1-yl)acetic acid;

2-(5-Methoxy-2-methyl-3-(6-oxo-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridin-3-yl)-1H-indol-1-yl)acetic acid;

1-(2,3-Difluorobenzyl)-5-(5-fluoro-2-methyl-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-1H-indol-3-yl)pyridin-2(1H)-one;

2-(3-(1-(2,3-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-5-fluoro-2-methyl-1H-indol-1-yl)-N,N-dimethylacetamide;

2-(3-(1-(2,3-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetamide;

2-(3-(1-(2,3-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-5-fluoro-2-methyl-1H-indol-1-yl)-N-(methylsulfonyl)acetamide;

3-(3-(1-(2,3-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-5-fluoro-2-methyl-1H-indol-1-yl)propanoic acid;

2-(2,5-Dimethyl-3-(6-oxo-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridin-3-yl)-1H-indol-1-yl)-acetic acid;

1-(2,3-Difluorobenzyl)-5-(5-fluoro-1-(2-hydroxyethyl)-2-methyl-1H-indol-3-yl)pyridin-2(1H)-one;

(S)-2-(3-(1-(2,3-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-5-fluoro-2-methyl-1H-indol-1-yl)propanoic acid;

(R)-2-(3-(1-(2,3-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-5-fluoro-2-methyl-1H-indol-1-yl)propanoic acid;

2-(5-Fluoro-2-methyl-3-(6-oxo-1-(3,3,3-trifluoropropyl)-1,6-dihydropyridin-3-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(6-oxo-1-(pyridin-4-ylmethyl)-1,6-dihydropyridin-3-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(6-oxo-1-(pyridin-2-ylmethyl)-1,6-dihydropyridin-3-yl)-1H-indol-1-yl)acetic acid;

2-(3-(1-(2,3-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetonitrile;

5-(1-((2H-Tetrazol-5-yl)methyl)-5-fluoro-2-methyl-1H-indol-3-yl)-1-(2,3-difluorobenzyl)-pyridin-2(1H)-one;

2-(3-(1-Benzyl-6-oxo-1,6-dihydropyridin-3-yl)-5-fluoro-2-methyl-1H-indol-1-yl)-N-(phenylsulfonyl)acetamide;

2-(3-(1-Benzyl-6-oxo-1,6-dihydropyridin-3-yl)-5-fluoro-2-methyl-1H-indol-1-yl)-N-(methyl-sulfonyl)acetamide;

2-(3-(1-Benzyl-6-oxo-1,6-dihydropyridin-3-yl)-5-fluoro-2-methyl-1H-indol-1-yl)-N-(o-tolyl-sulfonyl)acetamide;

2-(5-Fluoro-2-methyl-3-(6-oxo-1-(pyridin-3-ylmethyl)-1,6-dihydropyridin-3-yl)-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-(6-oxo-1-(4,4,4-trifluoro-3-(trifluoromethyl)butyl)-1,6-dihydro-pyridin-3-yl)-1H-indol-1-yl)acetic acid;

N-(Cyclopropylsulfonyl)-2-(5-fluoro-2-methyl-3-(6-oxo-1-(4,4,4-trifluorobutyl)-1,6-dihydropyridin-3-yl)-1H-indol-1-yl)acetamide;

2-(5-Fluoro-2-methyl-3-(6-oxo-1-(4,4,4-trifluorobutyl)-1,6-dihydropyridin-3-yl)-1-H-indol-1-yl)-N-(methylsulfonyl)acetamide;

2-(3-(1-Benzyl-6-oxo-1,6-dihydropyridin-3-yl)-5-fluoro-2-methyl-1H-indol-1-yl)-N-(cyclo-propyl-sulfonyl)acetamide;

2-(3-((1-(2,4-Difluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-5-fluoro-2-methyl-1H-indol-1-yl)-N-(methylsulfonyl)acetamide;

2-(3-((1-(3,4-Difluorobenzyl)-6-oxo-1,6-dihydropyridin-3-yl)methyl)-5-fluoro-2-methyl-1H-indol-1-yl)-N-(methylsulfonyl)acetamide;

2-(5-Chloro-2-methyl-3-(4-oxo-3-(2-phenoxyethyl)-3,4-dihydrophthalazin-1-yl)-1H-indol-1-yl)-N-(methylsulfonyl)acetamide;

2-(3-(2-Benzyl-1-oxo-1,2-dihydroisoquinolin-4-yl)-5-fluoro-2-methyl-1H-indol-1-yl)-N-(methylsulfonyl)acetamide;

2-(3-(1-Benzyl-6-oxo-1,6-dihydropyridazin-3-yl)-5-fluoro-2-methyl-1H-indol-1yl)acetic acid;

2-(3-(1-(2,4-Dichlorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

[3-(3-Isopropyl-4-oxo-3,4-dihydrophthalazin-1-yl)-2-methyl-1H-indol-1-yl]acetic acid;

{5-Fluoro-2-methyl-3-[3-(2-methylpropyl)-4-oxo-3,4-dihydrophthalazin-1-yl]-1H-indol-1-yl}acetic acid;

[3-(3-Benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)-5-fluoro-2-methyl-1H-indol-1-yl]acetic acid;

{5-Fluoro-3-[3-(3-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl]-2-methyl-1H-indol-1-yl}acetic acid;

{5-Fluoro-2-methyl-3-[3-(1-methylethyl)-4-oxo-3,4-dihydrophthalazin-1-yl]-1H-indol-1-yl}-acetic acid;

{5-Chloro-3-[3-(2,4-dichlorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl]-2-methyl-1H-indol-1-yl}acetic acid;

(5-Chloro-2-methyl-3-{3-[4-(methylsulfonyl)benzyl]-4-oxo-3,4-dihydrophthalazin-1-yl}-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-3-(1-isobutyl-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl)acetic acid;

[5-Fluoro-3-(1-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)-2-methyl-1H-indol-1-yl]acetic acid;

(3-{[1-(2,4-Difluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl]methyl}-2-methyl-1H-indol-1-yl)acetic acid;

(3-{[1(2,5-Difluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl]methyl}-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

{3-[(1-Benzyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl]-5-fluoro-2-methyl-1H-indol-1-yl}-acetic acid;

(3-{[1-(2,6-Difluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl]methyl}-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

(3-{[1(2,3-Difluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl]methyl}-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

(3-{[1-(2-Fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl]methyl}-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

(3-{[1(3-fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl]methyl}-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

(3-{[1-(4-Fluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl]methyl}-5-fluoro-2-methyl-1-H-indol-1-yl)acetic acid;

(3-{[1-(2,2-Dimethylpropyl)-6-oxo-1,6-dihydropyridazin-3-yl]methyl}-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid;

2-(5-Fluoro-2-methyl-3-((6-oxo-1-(4,4,4-trifluorobutyl)-1,6-dihydropyridazin-3-yl)methyl)-1H-indol-1-yl)acetic acid;

(5-Fluoro-2-methyl-3-{[6-oxo-1-(2,2,2-trifluoroethyl)-1,6-dihydropyridazin-3-yl]methyl}-1H-indol-1-yl)acetic acid;

{3-[(1-Benzyl-6-oxo-1,6-dihydropyridin-3-yl)methyl]-5-fluoro-2-methyl-1H-indol-1-yl}acetic acid;

{3-[(1-Benzyl-6-oxo-1,6-dihydropyridin-3-yl)methyl]-5-chloro-2-methyl-1H-indol-1-yl}acetic acid;

{3-[(1-Benzyl-6-oxo-1,6-dihydropyridin-3-yl)methyl]-2-methyl-1H-indol-1-yl}acetic acid; and

{3-[3-(2-amino-2-oxoethyl)-4-oxo-3,4-dihydrophthalazin-1-yl]-5-fluoro-2-methyl-1H-indol-1-yl}acetic acid or

a pharmaceutically acceptable salt thereof.

20. A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

21. A method of treating a disease or a disorder in a patient, comprising administering to a patient in need thereof a compound of claim 1 or a pharmaceutically acceptable salt thereof.

22. The method of claim 21, wherein the disease or disorder is selected from the group consisting of asthma, chronic obstructive pulmonary disease (COPD), bronchitis, rhinitis, nasal polyposis, sarcoidosis, farmer'"'"'s lung, fibroid lung, idiopathic intestinal pneumonia, cystic fibrosis, cough, psoriasis, dermatitis, urticaria, cutaneous eosinophilias, chronic sinusitis, eosinophilic esophagitis, eosinophilic gastroenteritis, eosinophilic colitis, eosinophilic fasciitis, lupus, rheumatoid arthritis, inflammatory Bowel disease, Celiac disease, scleroderma, ankylosing spondylitis, autoimmune diseases, allergic diseases and hyper IgE syndrome.

23. The method of claim 21, wherein the treatment of a disease or a disorder further comprises administering an additional therapeutic agent.

24. The method of claim 21, wherein the disease or disorder is characterized by elevated levels of prostaglandin D₂ (PGD₂) or a metabolite thereof.

25. The method of claim 21, wherein the disease or disorder is characterized by elevated levels of a thromboxane metabolite.

26. A method of inhibiting the binding of endogenous ligands to the CRTH-2 receptor in a cell, comprising contacting the cell with a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof.

27. The method of claim 26, wherein the endogenous ligand is prostaglandin D₂ (PGD₂) or a metabolite thereof.

28. The method of claim 26, wherein the endogenous ligand is a thromboxane metabolite.