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Copper-catalysed ligation of azides and acetylenes

  • US 20110105764A1
  • Filed: 07/26/2010
  • Published: 05/05/2011
  • Est. Priority Date: 05/30/2002
  • Status: Active Grant
First Claim
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1. A copper catalyzed process for preparing a 1,4-disubstituted 1,2,3-triazole comprising:

  • contacting an organic azide and a terminal alkyne with Cu(I) ion in the presence of a ligand for Cu(I) to form a 1,4-disubstituted 1,2,3-triazole compound;

    wherein the ligand for Cu(I) is selected from the group consisting of a nitrile, a nitrite, an isonitrile, a primary amine, a secondary amine, a carboxylate, chloride, an alcohol, a thiol, and a combination thereof.

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