Nanoparticle-sized magnetic absorption enhancers having three-dimensional geometries adapted for improved diagnostics and hyperthermic treatment
First Claim
1. A nanoparticle-sized magnetic absorption enhancer exhibiting a controlled response to a magnetic field, said magnetic absorption enhancer comprising:
- a) a magnetic material having an inductive thermal response to said magnetic field;
b) a coating embedding said magnetic material and conforming to a predetermined shape, thereby producing a controlled mechanical response of said magnetic absorption enhancer to said magnetic field; and
c) a targeting moiety for specific binding of said magnetic absorption enhancer to a pathogen target;
wherein said controlled response comprises said inductive thermal response and said controlled mechanical response.
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Accused Products
Abstract
Nanoparticle-sized magnetic absorption enhancers (MAEs) that exhibit a controlled response to a magnetic field, including a controlled mechanical response and inductive thermal response. The MAEs have a magnetic material that exhibits the inductive thermal response to the magnetic field and is embedded in a coating, such that the MAE conforms to a particular shape, e.g., a hemisphere, a dome or a shell, that is chosen to produce the desired controlled mechanical response of the entire MAE to the magnetic field. A targeting moiety for specifically binding the MAE to a pathogen target is also provided. The MAEs are preferably bound by a flexible linker to promote the desired mechanical response, which includes interactions between MAEs that are not bound to their pathogen target for the purpose of forming spheres, spherical shells, or generally spherical dimers. Such forms contain the thermal energy produced by the thermal inductive response of the magnetic material and thus reduce collateral healthy tissue damage during hyperthermic treatment. The inventing extends to appropriate apparatus and methods for diagnostics and hyperthermic treatments employing the MAEs.
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Citations
34 Claims
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1. A nanoparticle-sized magnetic absorption enhancer exhibiting a controlled response to a magnetic field, said magnetic absorption enhancer comprising:
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a) a magnetic material having an inductive thermal response to said magnetic field; b) a coating embedding said magnetic material and conforming to a predetermined shape, thereby producing a controlled mechanical response of said magnetic absorption enhancer to said magnetic field; and c) a targeting moiety for specific binding of said magnetic absorption enhancer to a pathogen target; wherein said controlled response comprises said inductive thermal response and said controlled mechanical response. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. An apparatus for inducing transient hyperthermia in a pathogen target, said apparatus comprising:
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a) a means for generating a magnetic field; b) a nanoparticle-sized magnetic absorption enhancer exhibiting a controlled response to said magnetic field and comprising; i) a magnetic material having an inductive thermal response to said magnetic field; ii) a coating embedding said magnetic material and conforming to a predetermined shape, thereby producing a controlled mechanical response of said magnetic absorption enhancer to said magnetic field; and iii) a targeting moiety for specific binding of said magnetic absorption enhancer to a pathogen target; wherein said controlled response comprises said inductive thermal response and said controlled mechanical response. - View Dependent Claims (23, 24, 25, 26)
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27. A method for inducing transient hyperthermia in a pathogen target, said method comprising the following steps:
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a) generating a magnetic field; b) producing a nanoparticle-sized magnetic absorption enhancer exhibiting a controlled response to said magnetic field by; i) providing a magnetic material having an inductive thermal response to said magnetic field; ii) embedding said magnetic material in a coating that conforms to a predetermined shape, thereby enabling a controlled mechanical response of said magnetic absorption enhancer to said magnetic field; and iii) providing a targeting moiety for specific binding of said magnetic absorption enhancer to a pathogen target; c) delivering said magnetic absorption enhancer to a region comprising said pathogen target for specific binding to said pathogen target; wherein said controlled response comprises said inductive thermal response and said controlled mechanical response. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34)
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Specification