MONITORING METHOD AND/OR APPARATUS
First Claim
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1. A method of in vivo monitoring of an individual'"'"'s interstitial fluid comprising:
- creating a plurality of fluid paths through a stratum corneum area of the individual'"'"'s skin, the fluid paths each comprising a distal end in fluid communication with interstitial fluid of the individual, a proximal end in analyte communication with a sensing area located outside of the patient'"'"'s body, and an interior space extending between the distal and proximal ends of the fluid path;
allowing at least one analyte to passively diffuse from the patient'"'"'s interstitial fluid through the fluid paths and into the sensing area; and
sensing a concentration of the at least one analyte in the sensing fluid using a sensor located at least partially in the sensing area.
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Abstract
A method and apparatus for substance monitoring. One application is an easy to handle continuous glucose monitor using a group of hollow out-of-plane silicon microneedles to sample substances in interstitial fluid from the epidermal skin layer. The glucose of the interstitial fluid permeates a dialysis membrane and reaches a sensor. Using MEMS technology, for example, allows well-established batch fabrication at low cost.
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Citations
12 Claims
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1. A method of in vivo monitoring of an individual'"'"'s interstitial fluid comprising:
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creating a plurality of fluid paths through a stratum corneum area of the individual'"'"'s skin, the fluid paths each comprising a distal end in fluid communication with interstitial fluid of the individual, a proximal end in analyte communication with a sensing area located outside of the patient'"'"'s body, and an interior space extending between the distal and proximal ends of the fluid path; allowing at least one analyte to passively diffuse from the patient'"'"'s interstitial fluid through the fluid paths and into the sensing area; and sensing a concentration of the at least one analyte in the sensing fluid using a sensor located at least partially in the sensing area. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification