Tissue Engineering In Vivo With Vascularized Scaffolds

• US 20110106250A1
• Filed: 11/12/2010
• Published: 05/05/2011
• Est. Priority Date: 10/13/2006
• Status: Active Grant

• Current Assignee: Biostruxs LLC
• Original Assignee: Biostruxs LLC
• Inventors: Brooks, Mai Nguyen, Watson, James P.
• Granted Patent: US 8,192,487 B2
• Time in Patent Office: Days
• US Class Current: 623/8
• CPC Class Codes: A61K 35/12 Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells vaccines or medicinal preparations containing antigens or antibodies A61K39/00
• CPC Class Codes: C12N 2533/40 Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers
• CPC Class Codes: C12N 5/0653 Adipocytes; Adipose tissue

Abstract

The field of the present invention relates to a novel method for producing tissue or organ in a mammal by implanting in vivo a novel three dimensional biodegradable scaffold. The novel three dimensional biodegradable scaffolds overcome the barrier of developing large organs with tissue engineering.

Claims

1-12. -12. (canceled)

13. A pair of breast implants comprising:

two growth chambers;

each chamber containing a combination of omentum and a tissue matrix

a blood supply connected to the omentum in each chamber

each chamber sized and shaped for placement in a breast of a patient.

14. A pair of breast implants according to claim 13, wherein said growth chambers are resorbable.

15. A pair of breast implants according to claim 13, wherein said growth chambers are comprised of a polymer.

16. A pair of breast implants according to claim 13, wherein said omentum comprises two split sections of omentum, one for each chamber.

17. A pair of breast implants according to claim 13, wherein said tissue matrix comprises harvested fat tissue.

18. A pair of breast implants according to claim 13, wherein said tissue matrix comprises harvested fat tissue and a nutrient.

19. A pair of breast implants according to claim 13, further comprising each chamber having at least one port.

20. A pair of breast implants according to claim 19, wherein said at least one port is connected to a source of growth media infusion.

21. A method of growing a pair of breast implants comprising:

providing two growth chambers for placement in a space of a patient;

splitting an omentum of said patient into two separate sections, each section having its own blood supply;

placing one of said sections of omentum into one of said growth chambers and the other of said sections of omentum into the other of said growth chambers;

allowing tissue to grow in each of said growth chambers;

placing said growth chambers in a breast of said patient while maintaining a blood supply to said omentum.

22. A method as set forth in claim 21, wherein the blood supply to said omentum is constituted by gastroepiploic blood vessels.

23. A method as set forth in claim 21, wherein said blood supply to said omentum is constituted by the axilla.

24. A method as set forth in claim 21, further comprising allowing each of said growth chambers to resorb.

25. A method as set forth in claim 21, further comprising mixing a tissue matrix with said omentum during placing of said omentum sections.

26. A method as set forth in claim 25, wherein the mixing of the tissue matrix with the omentum comprises mixing harvested fat tissue with said omentum.

27. A method as set forth in claim 26, wherein said mixing further includes mixing harvested tissue and a nutrient with said omentum.

28. A method as set forth in claim 21, wherein the growth of tissue in each of said growth chambers is monitored.

29. A method as set forth in claim 21, further comprising determining that said growth chambers are each full of tissue.

30. A method as set forth in claim 21, further comprising providing growth media to each of said two growth chambers.