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Combined Chemical and Genetic Approaches for Generation of Induced Pluripotent Stem Cells

  • US 20110110899A1
  • Filed: 03/17/2009
  • Published: 05/12/2011
  • Est. Priority Date: 03/17/2008
  • Status: Active Grant
First Claim
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1. A method of producing induced pluripotent stem cells from mammalian non-pluripotent cells, the method comprising, contacting the cells with at least one of:

  • an agent that inhibits H3K9 methylation or promotes H3K9 demethylation;

    an L-type Ca channel agonist;

    an activator of the cAMP pathway;

    DNA methyltransferase (DNMT) inhibitor;

    a nuclear receptor ligand;

    a GSK3 inhibitor;

    a MEK inhibitor;

    a TGFβ

    receptor/ALK5 inhibitor;

    a HDAC inhibitor; and

    an erk inhibitor, thereby producing induced pluripotent stem cells.

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